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Literature DB >> 10992521

Immunization with alpha-toxin toxoid protects the cornea against tissue damage during experimental Staphylococcus aureus keratitis.

E B Hume¹, J J Dajcs, J M Moreau, R J O'Callaghan.

Abstract

Alpha-toxin is a major virulence factor in Staphylococcus aureus keratitis. Active or passive immunization with alpha-toxin toxoid could protect against corneal damage. Results show that either form of immunization did not kill bacteria but did significantly protect against corneal pathology, especially epithelial erosion.

Entities: Disease

Mesh：

Substances：

Year: 2000 PMID： 10992521 PMCID： PMC101573 DOI： 10.1128/IAI.68.10.6052-6055.2000

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

23 in total

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18 in total

1. Immune modulation with a staphylococcal preparation in fibromyalgia/chronic fatigue syndrome: relation between antibody levels and clinical improvement.

Authors: O Zachrisson; P Colque-Navarro; C G Gottfries; B Regland; R Möllby
Journal: Eur J Clin Microbiol Infect Dis Date: 2004-01-20 Impact factor: 3.267

2. 2-O-Sulfated Domains in Syndecan-1 Heparan Sulfate Inhibit Neutrophil Cathelicidin and Promote Staphylococcus aureus Corneal Infection.

Authors: Atsuko Hayashida; Shiro Amano; Richard L Gallo; Robert J Linhardt; Jian Liu; Pyong Woo Park
Journal: J Biol Chem Date: 2015-04-30 Impact factor: 5.157

Review 3. Corneal ulceration in pediatric patients: a brief overview of progress in topical treatment.

Authors: Serina Stretton; Usha Gopinathan; Mark D P Willcox
Journal: Paediatr Drugs Date: 2002 Impact factor: 3.022

4. Active Immunization with Pneumolysin versus 23-Valent Polysaccharide Vaccine for Streptococcus pneumoniae Keratitis.

Authors: Erin W Norcross; Melissa E Sanders; Quincy C Moore; Sidney D Taylor; Nathan A Tullos; Rhonda R Caston; Sherrina N Dixon; Moon H Nahm; Robert L Burton; Hilary Thompson; Larry S McDaniel; Mary E Marquart
Journal: Invest Ophthalmol Vis Sci Date: 2011-11-29 Impact factor: 4.799

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Authors: Atsuko Hayashida; Shiro Amano; Pyong Woo Park
Journal: J Biol Chem Date: 2010-12-02 Impact factor: 5.157

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Authors: Tomás Maira-Litrán; Andrea Kropec; Donald A Goldmann; Gerald B Pier
Journal: Infect Immun Date: 2005-10 Impact factor: 3.441

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Journal: Infect Immun Date: 2006-10 Impact factor: 3.441

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Authors: Kellie Burnside; Annalisa Lembo; Melissa de Los Reyes; Anton Iliuk; Nguyen-Thao Binhtran; James E Connelly; Wan-Jung Lin; Byron Z Schmidt; Anthony R Richardson; Ferric C Fang; Weiguo Andy Tao; Lakshmi Rajagopal
Journal: PLoS One Date: 2010-06-11 Impact factor: 3.240

10. Protection from Streptococcus pneumoniae keratitis by passive immunization with pneumolysin antiserum.

Authors: Sherrina N Green; Melissa Sanders; Quincy C Moore; Erin W Norcross; Kathryn S Monds; Armando R Caballero; Larry S McDaniel; Sherrina A Robinson; Chinwendu Onwubiko; Richard J O'Callaghan; Mary E Marquart
Journal: Invest Ophthalmol Vis Sci Date: 2008-01 Impact factor: 4.799