Literature DB >> 10992518

Comparison of abilities of Salmonella enterica serovar typhimurium aroA aroD and aroA htrA mutants to act as live vectors.

M Roberts1, S Chatfield, D Pickard, J Li, A Bacon.   

Abstract

We compared the ability of Salmonella enterica serovar Typhimurium SL1344 aroA aroD (BRD509) and aroA htrA (BRD807) mutants to act as live vectors for delivery of fragment C of tetanus toxin (FrgC). FrgC was expressed in these strains from either pTETnir15 or pTEThtrA1. BRD509FrgC(+) strains elicited approximately 2-log-higher serum anti-FrgC antibody titers than BRD807FrgC(+) strains. All mice immunized with BRD807pTEThtrA1, BRD509pTEThtrA1, and BRD509pTETnir15 (but not BRD807pTETnir15) were protected against tetanus.

Entities:  

Mesh：

Substances：

Year:  2000        PMID： 10992518      PMCID： PMC101570          DOI： 10.1128/IAI.68.10.6041-6043.2000

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  12 in total

1.  Oral somatic transgene vaccination using attenuated S. typhimurium.

Authors:  A Darji; C A Guzmán; B Gerstel; P Wachholz; K N Timmis; J Wehland; T Chakraborty; S Weiss
Journal:  Cell       Date:  1997-12-12       Impact factor: 41.582

2.  Evaluation of Salmonella typhimurium strains harbouring defined mutations in htrA and aroA in the murine salmonellosis model.

Authors:  S N Chatfield; K Strahan; D Pickard; I G Charles; C E Hormaeche; G Dougan
Journal:  Microb Pathog       Date:  1992-02       Impact factor: 3.738

3.  Phase 2 clinical trial of attenuated Salmonella enterica serovar typhi oral live vector vaccine CVD 908-htrA in U.S. volunteers.

Authors:  C O Tacket; M B Sztein; S S Wasserman; G Losonsky; K L Kotloff; T L Wyant; J P Nataro; R Edelman; J Perry; P Bedford; D Brown; S Chatfield; G Dougan; M M Levine
Journal:  Infect Immun       Date:  2000-03       Impact factor: 3.441

4.  Comparison of the abilities of different attenuated Salmonella typhimurium strains to elicit humoral immune responses against a heterologous antigen.

Authors:  S J Dunstan; C P Simmons; R A Strugnell
Journal:  Infect Immun       Date:  1998-02       Impact factor: 3.441

5.  Prior immunity to homologous and heterologous Salmonella serotypes suppresses local and systemic anti-fragment C antibody responses and protection from tetanus toxin in mice immunized with Salmonella strains expressing fragment C.

Authors:  M Roberts; A Bacon; J Li; S Chatfield
Journal:  Infect Immun       Date:  1999-08       Impact factor: 3.441

6.  Safety of live oral Salmonella typhi vaccine strains with deletions in htrA and aroC aroD and immune response in humans.

Authors:  C O Tacket; M B Sztein; G A Losonsky; S S Wasserman; J P Nataro; R Edelman; D Pickard; G Dougan; S N Chatfield; M M Levine
Journal:  Infect Immun       Date:  1997-02       Impact factor: 3.441

7.  In vivo characterization of the murine intranasal model for assessing the immunogenicity of attenuated Salmonella enterica serovar Typhi strains as live mucosal vaccines and as live vectors.

Authors:  T E Pickett; M F Pasetti; J E Galen; M B Sztein; M M Levine
Journal:  Infect Immun       Date:  2000-01       Impact factor: 3.441

8.  Characterization of a Salmonella typhimurium aro vaccine strain expressing the P.69 antigen of Bordetella pertussis.

Authors:  R Strugnell; G Dougan; S Chatfield; I Charles; N Fairweather; J Tite; J L Li; J Beesley; M Roberts
Journal:  Infect Immun       Date:  1992-10       Impact factor: 3.441

9.  Comparison of the safety and immunogenicity of delta aroC delta aroD and delta cya delta crp Salmonella typhi strains in adult volunteers.

Authors:  C O Tacket; D M Hone; R Curtiss; S M Kelly; G Losonsky; L Guers; A M Harris; R Edelman; M M Levine
Journal:  Infect Immun       Date:  1992-02       Impact factor: 3.441

10.  Oral vaccination against tetanus: comparison of the immunogenicities of Salmonella strains expressing fragment C from the nirB and htrA promoters.

Authors:  M Roberts; J Li; A Bacon; S Chatfield
Journal:  Infect Immun       Date:  1998-07       Impact factor: 3.441
View more
  9 in total

1.  Surface display of domain III of Japanese encephalitis virus E protein on Salmonella typhimurium by using an ice nucleation protein.

Authors:  Jian-Lin Dou; Tao Jing; Jing-Jing Fan; Zhi-Ming Yuan
Journal:  Virol Sin       Date:  2011-12-10       Impact factor: 4.327

Review 2.  Bacterial infectious disease control by vaccine development.

Authors:  Roy Curtiss
Journal:  J Clin Invest       Date:  2002-10       Impact factor: 14.808

3.  Mucosally delivered Salmonella live vector vaccines elicit potent immune responses against a foreign antigen in neonatal mice born to naive and immune mothers.

Authors:  Alejandra V E Capozzo; Lilian Cuberos; Myron M Levine; Marcela F Pasetti
Journal:  Infect Immun       Date:  2004-08       Impact factor: 3.441

4.  Delivery of the immunosuppressive antigen Salp15 to antigen-presenting cells by Salmonella enterica serovar Typhimurium aroA mutants.

Authors:  Amir-Reza T Motameni; Ignacio J Juncadella; Shobana K Ananthanarayanan; Michael N Hedrick; Yvette Huet-Hudson; Juan Anguita
Journal:  Infect Immun       Date:  2004-06       Impact factor: 3.441

5.  Escherichia coli DegP protease cleaves between paired hydrophobic residues in a natural substrate: the PapA pilin.

Authors:  C Hal Jones; Paul Dexter; Amy K Evans; Christopher Liu; Scott J Hultgren; Dennis E Hruby
Journal:  J Bacteriol       Date:  2002-10       Impact factor: 3.490

6.  Dendritic cell targeting of Bacillus anthracis protective antigen expressed by Lactobacillus acidophilus protects mice from lethal challenge.

Authors:  M Mohamadzadeh; T Duong; S J Sandwick; T Hoover; T R Klaenhammer
Journal:  Proc Natl Acad Sci U S A       Date:  2009-02-25       Impact factor: 11.205

7.  Live bacterial vaccines--a review and identification of potential hazards.

Authors:  Ann Detmer; Jacob Glenting
Journal:  Microb Cell Fact       Date:  2006-06-23       Impact factor: 5.328

8.  Colonic immune stimulation by targeted oral vaccine.

Authors:  Mahesh Kathania; Mojgan Zadeh; Yaíma L Lightfoot; Robert M Roman; Bikash Sahay; Jeffrey R Abbott; Mansour Mohamadzadeh
Journal:  PLoS One       Date:  2013-01-30       Impact factor: 3.240

Review 9.  Lacticaseibacillus rhamnosus: A Suitable Candidate for the Construction of Novel Bioengineered Probiotic Strains for Targeted Pathogen Control.

Authors:  Moloko G Mathipa-Mdakane; Mapitsi S Thantsha
Journal:  Foods       Date:  2022-03-08
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.