Literature DB >> 109919

Nuclear transcripts of mouse heavy chain immunoglobulin genes contain only the expressed class of C-region sequences.

K B Marcu, U Schibler, R P Perry.   

Abstract

In plasmacytoma cells producing IgG, IgA, or IgM immunoglobulin heavy chains, the large precursors of the heavy chain messenger RNA's contain nucleotide sequences that specify only the expressed class of constant region. This indicates that the switch from one class of heavy chain to another during B cell ontogeny does not occur by altered processing of a complex gene transcript.

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Year:  1979        PMID： 109919     DOI： 10.1126/science.109919

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  14 in total

1.  Comparison of mRNA precursors in plasmacytomas producing closely related kappa chains.

Authors:  R P Perry; D E Kelley; U Schibler
Journal:  Proc Natl Acad Sci U S A       Date:  1979-08       Impact factor: 11.205

2.  Coexpression of mu and gamma 1 heavy chains can occur by a discontinuous transcription mechanism from the same unrearranged chromosome.

Authors:  M Nolan-Willard; M T Berton; P Tucker
Journal:  Proc Natl Acad Sci U S A       Date:  1992-02-15       Impact factor: 11.205

3.  Lack of class I H-2 antigens in cells transformed by radiation leukemia virus is associated with methylation and rearrangement of H-2 DNA.

Authors:  D Meruelo; R Kornreich; A Rossomando; C Pampeno; A Boral; J L Silver; J Buxbaum; E H Weiss; J J Devlin; A L Mellor
Journal:  Proc Natl Acad Sci U S A       Date:  1986-06       Impact factor: 11.205

4.  Molecular characterization of germ-line immunoglobulin A transcripts produced during transforming growth factor type beta-induced isotype switching.

Authors:  D A Lebman; D Y Nomura; R L Coffman; F D Lee
Journal:  Proc Natl Acad Sci U S A       Date:  1990-05       Impact factor: 11.205

5.  Preferential expression of variable region heavy chain gene segments by predominant 2,4-dinitrophenyl-specific BALB/c neonatal antibody clonotypes.

Authors:  S C Riley; S J Connors; N R Klinman; R T Ogata
Journal:  Proc Natl Acad Sci U S A       Date:  1986-04       Impact factor: 11.205

6.  Non-immunoglobulin-associated DNA rearrangements in mouse plasmacytomas.

Authors:  L J Harris; R B Lang; K B Marcu
Journal:  Proc Natl Acad Sci U S A       Date:  1982-07       Impact factor: 11.205

7.  Methylation patterns of immunoglobulin genes in lymphoid cells: correlation of expression and differentiation with undermethylation.

Authors:  U Storb; B Arp
Journal:  Proc Natl Acad Sci U S A       Date:  1983-11       Impact factor: 11.205

8.  Transcripts of the immunoglobulin C mu gene vary in structure and splicing during lymphoid development.

Authors:  D J Kemp; A W Harris; J M Adams
Journal:  Proc Natl Acad Sci U S A       Date:  1980-12       Impact factor: 11.205

9.  Rearrangement of immunoglobulin heavy chain genes during B-lymphocyte development as revealed by studies of mouse plasmacytoma cells.

Authors:  C Coleclough; D Cooper; R P Perry
Journal:  Proc Natl Acad Sci U S A       Date:  1980-03       Impact factor: 11.205

10.  Transcription of mouse kappa chain genes: implications for allelic exclusion.

Authors:  R P Perry; D E Kelley; C Coleclough; J G Seidman; P Leder; S Tonegawa; G Matthyssens; M Weigert
Journal:  Proc Natl Acad Sci U S A       Date:  1980-04       Impact factor: 11.205
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