Literature DB >> 10991885

A pharmacokinetic study of amphotericin B lipid complex injection (Abelcet) in patients with definite or probable systemic fungal infections.

A Adedoyin1, C E Swenson, L E Bolcsak, A Hellmann, D Radowska, G Horwith, A S Janoff, R A Branch.   

Abstract

This study describes a pharmacokinetic evaluation of amphotericin B (AMB) lipid complex injection (ABLC or Abelcet) in 17 patients with systemic fungal infection administered 5 mg/kg of body weight/day by infusion for 10 to 17 days. The results showed that AMB exhibited multiexponential disposition with high clearance, large volume of distribution at steady state, and long apparent elimination half-life but no evidence of accumulation in the blood after multiple daily doses. The results confirm previous observations and further reinforce the suggestion that ABLC may exist as a depot in the tissues from which free AMB is slowly released to limit exposure.

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Year:  2000        PMID： 10991885      PMCID： PMC90176          DOI： 10.1128/AAC.44.10.2900-2902.2000

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  13 in total

Review 1.  Antifungal agents. Part I. Amphotericin B preparations and flucytosine.

Authors:  R Patel
Journal:  Mayo Clin Proc       Date:  1998-12       Impact factor: 7.616

2.  In vitro and in vivo antifungal activity of amphotericin B lipid complex: are phospholipases important?

Authors:  C E Swenson; W R Perkins; P Roberts; I Ahmad; R Stevens; D A Stevens; A S Janoff
Journal:  Antimicrob Agents Chemother       Date:  1998-04       Impact factor: 5.191

3.  Safety, tolerance, and pharmacokinetics of amphotericin B lipid complex in children with hepatosplenic candidiasis.

Authors:  T J Walsh; P Whitcomb; S Piscitelli; W D Figg; S Hill; S J Chanock; P Jarosinski; R Gupta; P A Pizzo
Journal:  Antimicrob Agents Chemother       Date:  1997-09       Impact factor: 5.191

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Authors:  R Sabra; R A Branch
Journal:  Drug Saf       Date:  1990 Mar-Apr       Impact factor: 5.606

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Authors:  H A Gallis; R H Drew; W W Pickard
Journal:  Rev Infect Dis       Date:  1990 Mar-Apr

6.  Pharmacokinetic profile of ABELCET (amphotericin B lipid complex injection): combined experience from phase I and phase II studies.

Authors:  A Adedoyin; J F Bernardo; C E Swenson; L E Bolsack; G Horwith; S DeWit; E Kelly; J Klasterksy; J P Sculier; D DeValeriola; E Anaissie; G Lopez-Berestein; A Llanos-Cuentas; A Boyle; R A Branch
Journal:  Antimicrob Agents Chemother       Date:  1997-10       Impact factor: 5.191

7.  Unusual lipid structures selectively reduce the toxicity of amphotericin B.

Authors:  A S Janoff; L T Boni; M C Popescu; S R Minchey; P R Cullis; T D Madden; T Taraschi; S M Gruner; E Shyamsunder; M W Tate
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Review 8.  Amphotericin B and its delivery by liposomal and lipid formulations.

Authors:  C Gates; R J Pinney
Journal:  J Clin Pharm Ther       Date:  1993-06       Impact factor: 2.512

Review 9.  Liposomal and lipid formulations of amphotericin B. Clinical pharmacokinetics.

Authors:  R Janknegt; S de Marie; I A Bakker-Woudenberg; D J Crommelin
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10.  Comparative safety, tolerance, and pharmacokinetics of amphotericin B lipid complex and amphotericin B desoxycholate in healthy male volunteers.

Authors:  V L Kan; J E Bennett; M A Amantea; M C Smolskis; E McManus; D M Grasela; J W Sherman
Journal:  J Infect Dis       Date:  1991-08       Impact factor: 5.226
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Journal:  Antimicrob Agents Chemother       Date:  2007-01-29       Impact factor: 5.191

Review 6.  Amphotericin B lipid complex: in visceral leishmaniasis.

Authors:  David R Goldsmith; Caroline M Perry
Journal:  Drugs       Date:  2004       Impact factor: 9.546

Review 7.  Lipid Systems for the Delivery of Amphotericin B in Antifungal Therapy.

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Journal:  Pharmaceutics       Date:  2020-01-01       Impact factor: 6.321

8.  Sensitive LC-MS/MS Methods for Amphotericin B Analysis in Cerebrospinal Fluid, Plasma, Plasma Ultrafiltrate, and Urine: Application to Clinical Pharmacokinetics.

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  9 in total

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