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Literature DB >> 10991871

Anti-Candida activity of a new platinum derivative.

T Watanabe¹, M Takano, A Ogasawara, T Mikami, T Kobayashi, M Watabe, T Matsumoto.

Abstract

A new platinum derivative of the form H[Pt(IV)(Hdigly)Cl(2)(OH)(2)] (Hdigly==glycylglycine) damaged the Candida albicans cell membrane and inhibited the growth of the cells. The cytotoxic activity of H[Pt(IV)(Hdigly)Cl(2)(OH)(2)] on mammalian cells was 10-fold lower than that of cis-diammine-dichloroplatinum (cisplatin). Substitution of platinum for peptides is effective for enhancement of antifungal activity and reduction of the toxicity to mammalian cells.

Entities: Chemical Disease Species

Mesh：

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Year: 2000 PMID： 10991871 PMCID： PMC90162 DOI： 10.1128/AAC.44.10.2853-2854.2000

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

13 in total

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Authors: S A Ahmed; R M Gogal; J E Walsh
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Anti-Candida activity of a new platinum derivative.

1. Total sodium, potassium and chloride in adult man.

2. Full-length CD4 electroinserted in the erythrocyte membrane as a long-lived inhibitor of infection by human immunodeficiency virus.

Review 3. Putative virulence factors of Candida albicans.

4. Comparison of D0870, a new triazole antifungal agent, to fluconazole for inhibition of Candida albicans cytochrome P-450 by using in vitro assays.

5. Growth inhibition of rat mammary carcinoma induced by cis-platinum diamminodichloride-II.

6. The successful regression of large solid sarcoma 180 tumors by platinum compounds.

7. Platinum compounds: a new class of potent antitumour agents.

8. A new rapid and simple non-radioactive assay to monitor and determine the proliferation of lymphocytes: an alternative to [3H]thymidine incorporation assay.

9. DNA modifications by antitumor trans-[PtCl2(E-iminoether)2].

10. The cytotoxic action of four ammine/amine platinum(IV) dicarboxylates: a flow cytometric study.

Review 1. Antifungal activity of nonantifungal drugs.

2. Morphological and growth altering effects of Cisplatin in C. albicans using fluorescence microscopy.