Literature DB >> 1099118

A morphological basis for intercellular communication between alpha- and beta-cells in the endocrine pancreas.

L Orci, F Malaisse-Lagae, M Ravazzola, D Rouiller, A E Renold, A Perrelet, R Unger.   

Abstract

By degranulating beta-cells in the islets of Langerhans of the rat with sulfonylurea, it has been possible to distinguish unambiguously alpha-cells from beta-cells in freeze-fracture replicas. In such preparations, we found morphologically typical tight and gap junctions occurring between alpha- and beta-cells. The presence of gap junctions offers indirect evidence that these cells are coupled with one another; coupling may influence the secretory behavior of alpha- and beta-cells maintaining glucose homeostasis within tightly constricted limits.

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Year:  1975        PMID： 1099118      PMCID： PMC301963          DOI： 10.1172/JCI108154

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  12 in total

Review 1.  A portrait of the pancreatic B-cell. The Minkowski Award Lecture delivered on July 19, 1973, during the 8th Congress of the International Diabetes Federation, held in Brussels, Belgium.

Authors:  L Orci
Journal:  Diabetologia       Date:  1974-06       Impact factor: 10.122

Review 2.  Alpha- and beta-cell interrelationships in health and disease.

Authors:  R H Unger
Journal:  Metabolism       Date:  1974-06       Impact factor: 8.694

3.  Structural coupling between pancreatic islet cells.

Authors:  L Orci; R H Unger; A E Renold
Journal:  Experientia       Date:  1973-08-15

4.  Metabolic coupling, ionic coupling and cell contacts.

Authors:  N B Gilula; O R Reeves; A Steinbach
Journal:  Nature       Date:  1972-02-04       Impact factor: 49.962

Review 5.  Structure and function of intercellular junctions.

Authors:  L A Staehelin
Journal:  Int Rev Cytol       Date:  1974

6.  Junctions between cancer cells in culture: ultrastructure and permeability.

Authors:  R G Johnson; J D Sheridan
Journal:  Science       Date:  1971-11-12       Impact factor: 47.728

Review 7.  Membrane ultrastructure at mammalian intercellular junctions.

Authors:  N S McNutt; R S Weinstein
Journal:  Prog Biophys Mol Biol       Date:  1973       Impact factor: 3.667

Review 8.  Function of electrotonic junctions in embryonic and adult tissues.

Authors:  M V Bennett
Journal:  Fed Proc       Date:  1973-01

9.  [Ultrastructural events associated with the action of tolbutamide and glybenclamide on pancreatic B-cells in vivo and in vitro].

Authors:  L Orci; W Stauffacher; A E Renold; D Beaven; A Lambert; C Rouiller
Journal:  Acta Diabetol Lat       Date:  1969-09

10.  Method for the isolation of intact islets of Langerhans from the rat pancreas.

Authors:  P E Lacy; M Kostianovsky
Journal:  Diabetes       Date:  1967-01       Impact factor: 9.461
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  42 in total

1.  The chromogranins and the counter-regulatory hormones: do they make homeostatic sense?

Authors:  J H Koeslag; P T Saunders; J A Wessels
Journal:  J Physiol       Date:  1999-06-15       Impact factor: 5.182

2.  Identification of proliferative and mature β-cells in the islets of Langerhans.

Authors:  Erik Bader; Adriana Migliorini; Moritz Gegg; Noah Moruzzi; Jantje Gerdes; Sara S Roscioni; Mostafa Bakhti; Elisabeth Brandl; Martin Irmler; Johannes Beckers; Michaela Aichler; Annette Feuchtinger; Christin Leitzinger; Hans Zischka; Rui Wang-Sattler; Martin Jastroch; Matthias Tschöp; Fausto Machicao; Harald Staiger; Hans-Ulrich Häring; Helena Chmelova; Julie A Chouinard; Nikolay Oskolkov; Olle Korsgren; Stephan Speier; Heiko Lickert
Journal:  Nature       Date:  2016-07-11       Impact factor: 49.962

3.  Altered anomeric specificity of glucose-induced insulin release in rabbits with duct-ligated pancreas.

Authors:  F Fichaux; J Marchand; B Yaylali; V Leclercq-Meyer; J Catala; W J Malaisse
Journal:  Int J Pancreatol       Date:  1991-02

4.  Islet alpha-cells do not influence insulin secretion from beta-cells through cell-cell contact.

Authors:  Helen Brereton; Melanie J Carvell; Shanta J Persaud; Peter M Jones
Journal:  Endocrine       Date:  2007-02       Impact factor: 3.633

5.  The dynamics of insulin release from mouse pancreatic islet cells in suspension.

Authors:  L A Idahl; A Lernmark; J Sehlin; I B Täljedal
Journal:  Pflugers Arch       Date:  1976-11-05       Impact factor: 3.657

6.  The role of calcium in glucagon release, interactions between glucose and calcium.

Authors:  V Leclercq-Meyer; J Marchand; W J Malaisse
Journal:  Diabetologia       Date:  1976-10       Impact factor: 10.122

7.  Insulin secretion from perifused rat pancreatic pseudoislets.

Authors:  D W Hopcroft; D R Mason; R S Scott
Journal:  In Vitro Cell Dev Biol       Date:  1985-08

8.  Effects of glucose and glucagon on the fructose 2,6-bisphosphate content of pancreatic islets and purified pancreatic B-cells. A comparison with isolated hepatocytes.

Authors:  A Sener; E Van Schaftingen; M Van de Winkel; D G Pipeleers; F Malaisse-Lagae; W J Malaisse; H G Hers
Journal:  Biochem J       Date:  1984-08-01       Impact factor: 3.857

9.  Glucagon gene transcription is negatively regulated by insulin in a hamster islet cell line.

Authors:  J Philippe
Journal:  J Clin Invest       Date:  1989-08       Impact factor: 14.808

10.  Interactions between autonomic nerves and endocrine cells of the gastroenteropancreatic system.

Authors:  P H Smith; Katherine L Madson
Journal:  Diabetologia       Date:  1981-03       Impact factor: 10.122
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