| Literature DB >> 10990373 |
D Rotin1.
Abstract
The epithelial sodium channel (ENaC) plays a key role in the regulation of fluid absorption in the kidney, lung, colon and exocrine glands, and in the regulation of blood pressure. Abnormal functioning of ENaC is associated with several human diseases, including pseudohypoaldosteronism type I, Liddle's syndrome, pulmonary edema, and cystic fibrosis. ENaC is regulated by several hormones, ions and accessory proteins. This review focuses on the regulation of ENaC by recently described accessory proteins, mainly Nedd4, syntaxin 1A, CFTR, sgk, K-Ras2A and Cap-1.Entities:
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Year: 2000 PMID: 10990373 DOI: 10.1097/00041552-200009000-00012
Source DB: PubMed Journal: Curr Opin Nephrol Hypertens ISSN: 1062-4821 Impact factor: 2.894