Geropharmacology for the rheumatologist.

Drug administration to older patients with rheumatic disease is a challenge because they are more likely to have adverse drug reactions compared with younger patients. Elderly patients are at risk for adverse drug effects because they often have multiple acute and chronic illnesses and are on several prescription and over-the-counter medications. This article will enhance the practitioner's understanding of how disease and age modulate the pharmacokinetics and pharmacodynamics of medications commonly prescribed for rheumatic disorders. Minimizing the number of drugs prescribed, starting medications at low doses and increasing slowly, and monitoring for toxicity are especially important in the elderly. With judicious use of medications, the quality of life of older patients with rheumatic disease can be enhanced.