Literature DB >> 10989120

Transgenic methods for increasing Drosophila life span.

J Tower1.   

Abstract

At least five different transgenic approaches have been applied to the study of Drosophila aging. There are two single component systems: transgenes with native (normal) promoters and transgenes with heterologous promoters; as well as three binary systems: 'GAL4/UAS', 'FLP-out' and 'tet-on'. These approaches vary in ability to meet several technical challenges, and the relative advantages and disadvantages of each are discussed. Using these techniques, over-expression of the hsp70, Cu/ZnSOD and MnSOD genes has each been demonstrated to increase Drosophila life span.

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Year:  2000        PMID： 10989120     DOI： 10.1016/s0047-6374(00)00152-4

Source DB:  PubMed          Journal:  Mech Ageing Dev        ISSN： 0047-6374            Impact factor:   5.432


  28 in total

1.  Life extension in Drosophila by feeding a drug.

Authors:  Hyung-Lyun Kang; Seymour Benzer; Kyung-Tai Min
Journal:  Proc Natl Acad Sci U S A       Date:  2002-01-15       Impact factor: 11.205

2.  Metabolic regulation of manganese superoxide dismutase expression via essential amino acid deprivation.

Authors:  Kimberly J Aiken; Justin S Bickford; Michael S Kilberg; Harry S Nick
Journal:  J Biol Chem       Date:  2008-01-10       Impact factor: 5.157

3.  The influence of pro-longevity gene Gclc overexpression on the age-dependent changes in Drosophila transcriptome and biological functions.

Authors:  Alexey Moskalev; Mikhail Shaposhnikov; Ekaterina Proshkina; Alexey Belyi; Alexander Fedintsev; Svetlana Zhikrivetskaya; Zulfiya Guvatova; Asiya Sadritdinova; Anastasia Snezhkina; George Krasnov; Anna Kudryavtseva
Journal:  BMC Genomics       Date:  2016-12-28       Impact factor: 3.969

4.  Stem cell aging in the Drosophila ovary.

Authors:  Morris Waskar; Yishi Li; John Tower
Journal:  Age (Dordr)       Date:  2005-12-31

5.  Long live the queen: studying aging in social insects.

Authors:  Stephanie Jemielity; Michel Chapuisat; Joel D Parker; Laurent Keller
Journal:  Age (Dordr)       Date:  2005-12-31

6.  Endogenously imprinted genes in Drosophila melanogaster.

Authors:  Lori A McEachern; Nicholas J Bartlett; Vett K Lloyd
Journal:  Mol Genet Genomics       Date:  2014-08       Impact factor: 3.291

7.  Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones.

Authors:  James F Morley; Richard I Morimoto
Journal:  Mol Biol Cell       Date:  2003-12-10       Impact factor: 4.138

8.  A screen of apoptosis and senescence regulatory genes for life span effects when over-expressed in Drosophila.

Authors:  Jie Shen; Christina Curtis; Simon Tavaré; John Tower
Journal:  Aging (Albany NY)       Date:  2009-01-30       Impact factor: 5.682

9.  Induced overexpression of mitochondrial Mn-superoxide dismutase extends the life span of adult Drosophila melanogaster.

Authors:  Jingtao Sun; Donna Folk; Timothy J Bradley; John Tower
Journal:  Genetics       Date:  2002-06       Impact factor: 4.562

Review 10.  What have two decades of laboratory life-history evolution studies on Drosophila melanogaster taught us?

Authors:  N G Prasad; Amitabh Joshi
Journal:  J Genet       Date:  2003 Apr-Aug       Impact factor: 1.166
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