Literature DB >> 10988333

Expression and immunolocalization of multidrug resistance protein 2 in rabbit small intestine.

R A Van Aubel1, A Hartog, R J Bindels, C H Van Os, F G Russel.   

Abstract

Multidrug resistance protein 2 (MRP2) is an ATP-dependent transporter of anionic drugs and conjugates. It functions as an efflux pump in the apical membranes of liver and kidney cells, but its membrane localization in small intestine has not yet been defined. The present study demonstrates exclusive localization of Mrp2 to the brush-border (apical) membrane of villi, decreasing in intensity from the villus tip to the crypts. In immunoblot analysis of crude membranes of various rabbit tissues, Mrp2 was only found in small intestine, kidney and liver. These results are in-line with the supposed function of Mrp2 in drug excretion.

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Year:  2000        PMID： 10988333     DOI： 10.1016/s0014-2999(00)00391-5

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  8 in total

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7.  Multidrug resistance-associated transporter 2 regulates mucosal inflammation by facilitating the synthesis of hepoxilin A3.

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Review 8.  Pharmacology of morphine in obese patients: clinical implications.

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  8 in total

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