| Literature DB >> 10988246 |
Abstract
Sulfation is a critical modification in many instances of biological recognition. Early work in lymphocyte homing indicated that the endothelial ligands for L-selectin depended upon sulfation modifications. Subsequent studies showed that the two specific modifications, Gal-6-SO4 and GlcNAc-6-SO4, were present on actual biological ligands. Recently, a family of carbohydrate sulfotransferases capable of generating these modifications has been identified at the molecular level. Reconstitution experiments implicate members of this family as critical participants in lymphocyte homing.Entities:
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Year: 2000 PMID: 10988246 DOI: 10.1093/glycob/10.9.849
Source DB: PubMed Journal: Glycobiology ISSN: 0959-6658 Impact factor: 4.313