Literature DB >> 10987958

Synthesis of cyclic peptides by ring-closing metathesis.

J F Reichwein1, C Versluis, R M Liskamp.   

Abstract

The synthesis of a series of "amide to amide" cyclized peptides by ring-closing metathesis (RCM) as well as a convenient synthesis for the linear precursors is described. In addition, the influence of the length of the alkene substituents and the influence of the peptide sequence is investigated, leading to a set of general rules to obtain "amide to amide" cyclized peptides by RCM.

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Year:  2000        PMID： 10987958     DOI： 10.1021/jo000759t

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  5 in total

1.  Design, synthesis, and opioid activity of arodyn analogs cyclized by ring-closing metathesis involving Tyr(allyl).

Authors:  Wei-Jie Fang; Thomas F Murray; Jane V Aldrich
Journal:  Bioorg Med Chem       Date:  2017-11-21       Impact factor: 3.641

2.  A Synthetic Loop Replacement Peptide That Blocks Canonical NF-κB Signaling.

Authors:  Paul A Bruno; Alex Morriss-Andrews; Andrew R Henderson; Charles L Brooks; Anna K Mapp
Journal:  Angew Chem Int Ed Engl       Date:  2016-10-28       Impact factor: 15.336

3.  Two-Steps Hantzsch Based Macrocyclization Approach for the Synthesis of Thiazole Containing Cyclopeptides.

Authors:  Adel Nefzi; Sergey Arutyunyan; Jason E Fenwick
Journal:  J Org Chem       Date:  2010-11-19       Impact factor: 4.354

4.  Design, synthesis, and pharmacological activities of dynorphin A analogues cyclized by ring-closing metathesis.

Authors:  Wei-Jie Fang; Yanjun Cui; Thomas F Murray; Jane V Aldrich
Journal:  J Med Chem       Date:  2009-09-24       Impact factor: 7.446

5.  Application of ring-closing metathesis macrocyclization to the development of Tsg101-binding antagonists.

Authors:  Fa Liu; Andrew G Stephen; Abdul A Waheed; Eric O Freed; Robert J Fisher; Terrence R Burke
Journal:  Bioorg Med Chem Lett       Date:  2009-10-29       Impact factor: 2.823
  5 in total

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