D Sander1, K Winbeck, J Klingelhöfer, B Conrad. 1. Department of Neurology, Technical University of Munich, Möhlstrasse 28, 81675 München, Germany. DirkSander@neuro.med.tu-muenchen.de
Abstract
OBJECTIVE: To evaluate the relationship between circadian blood pressure patterns and the extent of cerebral white matter lesions (WML). DESIGN: Case-control study. PARTICIPANTS: A total of 227 healthy subjects older than 55 years were investigated. Extent and occurrence of WML were evaluated using a computer-supported image analysis system. Circadian blood pressure variation was defined as the average percentage change of nighttime blood pressure compared with the daily blood pressure values. RESULTS: Subjects with WML were significantly older and showed more often a history of hypertension, elevated average systolic daily blood pressure, a reduced systolic circadian blood pressure variation, and an increased incidence of pathological nighttime blood pressure increases. A significant correlation was found between systolic circadian blood pressure variation and the extent of WML. A multiple regression analysis revealed that this parameter was best correlated with the extent of WML. CONCLUSION: In addition to the absolute level of blood pressure, systolic circadian blood pressure variation and in particular a systolic nighttime blood pressure increase may play an important role in the pathogenesis of WML.
OBJECTIVE: To evaluate the relationship between circadian blood pressure patterns and the extent of cerebral white matter lesions (WML). DESIGN: Case-control study. PARTICIPANTS: A total of 227 healthy subjects older than 55 years were investigated. Extent and occurrence of WML were evaluated using a computer-supported image analysis system. Circadian blood pressure variation was defined as the average percentage change of nighttime blood pressure compared with the daily blood pressure values. RESULTS: Subjects with WML were significantly older and showed more often a history of hypertension, elevated average systolic daily blood pressure, a reduced systolic circadian blood pressure variation, and an increased incidence of pathological nighttime blood pressure increases. A significant correlation was found between systolic circadian blood pressure variation and the extent of WML. A multiple regression analysis revealed that this parameter was best correlated with the extent of WML. CONCLUSION: In addition to the absolute level of blood pressure, systolic circadian blood pressure variation and in particular a systolic nighttime blood pressure increase may play an important role in the pathogenesis of WML.
Authors: Jesus D Melgarejo; Daniel C Aguirre-Acevedo; Ciro Gaona; Carlos A Chavez; Gustavo E Calmón; Eglé R Silva; Gabriel A de Erausquin; Mario Gil; Luis J Mena; Joseph D Terwilliger; Humberto Arboleda; Nikolaos Scarmeas; Joseph H Lee; Gladys E Maestre Journal: J Alzheimers Dis Date: 2020 Impact factor: 4.472
Authors: Caterina Rosano; Kaleab Z Abebe; Howard J Aizenstein; Robert Boudreau; J Richard Jennings; Vijay Venkatraman; Tamara B Harris; Kristine Yaffe; Suzanne Satterfield; Anne B Newman Journal: Am J Hypertens Date: 2014-08-26 Impact factor: 2.689
Authors: Annlia Paganini-Hill; Natalie Bryant; Maria M Corrada; Dana E Greenia; Evan Fletcher; Baljeet Singh; David Floriolli; Claudia H Kawas; Mark J Fisher Journal: Front Aging Neurosci Date: 2019-04-17 Impact factor: 5.750