BACKGROUND: Epidemiologic studies have indicated that human herpesvirus 8 is implicated in the development of Kaposi sarcoma in different geographic areas worldwide. GOAL: To provide information on the prevalence of human herpesvirus 8 in Brazil and its association with Kaposi sarcoma. STUDY DESIGN: An immunofluorescence assay was performed to test 1,044 serum samples from 747 blood donors, 73 patients presenting to casualty departments, and 224 patients attending sexually transmitted disease/AIDS clinics. The sexually transmitted disease group was composed of 88 patients with HIV (40 Kaposi sarcoma positive, 48 Kaposi sarcoma negative) and 136 patients without HIV. RESULTS: Antibodies to human herpesvirus 8-latent nuclear antigens were found in 34 blood donors (4.6%), and in seven casualty patients (9.6%). The highest frequency of human herpesvirus 8 antibodies was found in the sexually transmitted disease group: 32 HIV-positive patients with Kaposi sarcoma (80%) and seven patients without Kaposi sarcoma (14.6%). CONCLUSION: The presence of human herpesvirus 8 in patients with HIV was strongly associated with Kaposi sarcoma (odds ratio, 23.4; 95% CI, 7.7-71.4), male gender, homosexual or bisexual orientation, and hepatitis B virus infection, but not with the other sexually transmitted diseases that were investigated.
BACKGROUND: Epidemiologic studies have indicated that human herpesvirus 8 is implicated in the development of Kaposi sarcoma in different geographic areas worldwide. GOAL: To provide information on the prevalence of human herpesvirus 8 in Brazil and its association with Kaposi sarcoma. STUDY DESIGN: An immunofluorescence assay was performed to test 1,044 serum samples from 747 blood donors, 73 patients presenting to casualty departments, and 224 patients attending sexually transmitted disease/AIDS clinics. The sexually transmitted disease group was composed of 88 patients with HIV (40 Kaposi sarcoma positive, 48 Kaposi sarcoma negative) and 136 patients without HIV. RESULTS: Antibodies to human herpesvirus 8-latent nuclear antigens were found in 34 blood donors (4.6%), and in seven casualty patients (9.6%). The highest frequency of human herpesvirus 8 antibodies was found in the sexually transmitted disease group: 32 HIV-positive patients with Kaposi sarcoma (80%) and seven patients without Kaposi sarcoma (14.6%). CONCLUSION: The presence of human herpesvirus 8 in patients with HIV was strongly associated with Kaposi sarcoma (odds ratio, 23.4; 95% CI, 7.7-71.4), male gender, homosexual or bisexual orientation, and hepatitis B virus infection, but not with the other sexually transmitted diseases that were investigated.
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Keywords:
Acquired Immunodeficiency Syndrome; Americas; Brazil; Cancer; Clinical Research; Developing Countries; Diseases; Epidemiology; Health; Hiv Infections; Infections; Latin America; Neoplasms; Public Health; Reproductive Tract Infections; Research Methodology; Research Report; Sexually Transmitted Diseases; South America; Viral Diseases
Authors: Mariana Dias Batista; Suzete Ferreira; Mariana M Sauer; Helena Tomiyama; Maria Teresa Maidana Giret; Cláudio S Pannuti; Ricardo S Diaz; Ester C Sabino; Esper G Kallas Journal: PLoS One Date: 2009-05-19 Impact factor: 3.240
Authors: Jessica L Castilho; Ahra Kim; Cathy A Jenkins; Beatriz Grinsztejn; Eduardo Gotuzzo; Valeria Fink; Denis Padgett; Pablo F Belaunzaran-Zamudio; Brenda Crabtree-Ramírez; Maria Mercedes Escuder; Rosa Alencar Souza; Simone B Tenore; Sidnei R Pimentel; Maria Letícia Rodrigues Ikeda; Paulo R de Alencastro; Unai Tupinanbas; Carlos Brites; Estela Luz; Juliana Netto; Claudia P Cortes; Alexandre Grangeiro; Bryan E Shepherd; Catherine C McGowan Journal: J Int AIDS Soc Date: 2021-01 Impact factor: 6.707