| Literature DB >> 10987434 |
G S Welmaker1, J A Nelson, J E Sabalski, A L Sabb, J R Potoski, D Graziano, M Kagan, J Coupet, J Dunlop, H Mazandarani, S Rosenzweig-Lipson, S Sukoff, Y Zhang.
Abstract
A series of 2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5-(6H)ones and 2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoxalines was shown to exhibit 5-HT2C agonist binding and functional activity. Compound 21R inhibited food intake over 2 h in fasted, male Sprague Dawley rats with ED50 values of 2 mg/kg (i.p.) and 10 mg/kg (p.o.).Entities:
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Year: 2000 PMID： 10987434 DOI： 10.1016/s0960-894x(00)00400-5
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823