Literature DB >> 10987430

Substituted 2-aminopyridines as inhibitors of nitric oxide synthases.

W K Hagmann1, C G Caldwell, P Chen, P L Durette, C K Esser, T J Lanza, I E Kopka, R Guthikonda, S K Shah, M MacCoss, R M Chabin, D Fletcher, S K Grant, B G Green, J L Humes, T M Kelly, S Luell, R Meurer, V Moore, S G Pacholok, T Pavia, H R Williams, K K Wong.   

Abstract

A series of substituted 2-aminopyridines was prepared and evaluated as inhibitors of human nitric oxide synthases (NOS). 4,6-Disubstitution enhanced both potency and specificity for the inducible NOS with the most potent compound having an IC50 of 28 nM.

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Year:  2000        PMID： 10987430     DOI： 10.1016/s0960-894x(00)00389-9

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  14 in total

1.  Symmetric double-headed aminopyridines, a novel strategy for potent and membrane-permeable inhibitors of neuronal nitric oxide synthase.

Authors:  Fengtian Xue; Jianguo Fang; Silvia L Delker; Huiying Li; Pavel Martásek; Linda J Roman; Thomas L Poulos; Richard B Silverman
Journal:  J Med Chem       Date:  2011-03-16       Impact factor: 7.446

Review 2.  Nitric oxide synthase and structure-based inhibitor design.

Authors:  Thomas L Poulos; Huiying Li
Journal:  Nitric Oxide       Date:  2016-11-23       Impact factor: 4.427

3.  2-Aminopyridines with a Truncated Side Chain To Improve Human Neuronal Nitric Oxide Synthase Inhibitory Potency and Selectivity.

Authors:  Soosung Kang; Huiying Li; Wei Tang; Pavel Martásek; Linda J Roman; Thomas L Poulos; Richard B Silverman
Journal:  J Med Chem       Date:  2015-07-10       Impact factor: 7.446

4.  Microwave-assisted protection of primary amines as 2,5-dimethylpyrroles and their orthogonal deprotection.

Authors:  Amit Walia; Soosung Kang; Richard B Silverman
Journal:  J Org Chem       Date:  2013-10-14       Impact factor: 4.354

Review 5.  Target- and mechanism-based therapeutics for neurodegenerative diseases: strength in numbers.

Authors:  Paul C Trippier; Kristin Jansen Labby; Dustin D Hawker; Jan J Mataka; Richard B Silverman
Journal:  J Med Chem       Date:  2013-03-27       Impact factor: 7.446

6.  Synthesis and enzymatic evaluation of 2- and 4-aminothiazole-based inhibitors of neuronal nitric oxide synthase.

Authors:  Graham R Lawton; Haitao Ji; Pavel Martásek; Linda J Roman; Richard B Silverman
Journal:  Beilstein J Org Chem       Date:  2009-06-04       Impact factor: 2.883

Review 7.  Development of nitric oxide synthase inhibitors for neurodegeneration and neuropathic pain.

Authors:  Paramita Mukherjee; Maris A Cinelli; Soosung Kang; Richard B Silverman
Journal:  Chem Soc Rev       Date:  2014-10-07       Impact factor: 54.564

8.  Concise route to the chiral pyrrolidine core of selective inhibitors of neuronal nitric oxide.

Authors:  Fengtian Xue; Wenxin Gu; Richard B Silverman
Journal:  Org Lett       Date:  2009-11-19       Impact factor: 6.005

9.  Design and synthesis of 2-amino-4-methylpyridine analogues as inhibitors for inducible nitric oxide synthase and in vivo evaluation of [18F]6-(2-fluoropropyl)-4-methyl-pyridin-2-amine as a potential PET tracer for inducible nitric oxide synthase.

Authors:  Dong Zhou; Hsiaoju Lee; Justin M Rothfuss; Delphine L Chen; Datta E Ponde; Michael J Welch; Robert H Mach
Journal:  J Med Chem       Date:  2009-04-23       Impact factor: 7.446

10.  Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase.

Authors:  Elsa D Garcin; Andrew S Arvai; Robin J Rosenfeld; Matt D Kroeger; Brian R Crane; Gunilla Andersson; Glen Andrews; Peter J Hamley; Philip R Mallinder; David J Nicholls; Stephen A St-Gallay; Alan C Tinker; Nigel P Gensmantel; Antonio Mete; David R Cheshire; Stephen Connolly; Dennis J Stuehr; Anders Aberg; Alan V Wallace; John A Tainer; Elizabeth D Getzoff
Journal:  Nat Chem Biol       Date:  2008-10-12       Impact factor: 15.040
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