Literature DB >> 10987426

Lipopolyamines incorporating the tetraamine spermine, bound to an alkyl chain, sequester bacterial lipopolysaccharide.

I S Blagbrough1, A J Geall, S A David.   

Abstract

Lipopolyamines, with high affinity for calf thymus DNA in an ethidium bromide displacement assay, bind with high affinity to bacterial lipopolysaccharide and neutralise in vitro endotoxic activity as determined by Griess nitric oxide and TNF-alpha ELISA assays.

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Year:  2000        PMID： 10987426     DOI： 10.1016/s0960-894x(00)00380-2

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  8 in total

1.  Bacterial cell wall compounds as promising targets of antimicrobial agents I. Antimicrobial peptides and lipopolyamines.

Authors:  Guillermo Martínez de Tejada; Susana Sánchez-Gómez; Iosu Rázquin-Olazaran; Ina Kowalski; Yani Kaconis; Lena Heinbockel; Jörg Andrä; Tobias Schürholz; Mathias Hornef; Aline Dupont; Patrick Garidel; Karl Lohner; Thomas Gutsmann; Sunil A David; Klaus Brandenburg
Journal:  Curr Drug Targets       Date:  2012-08       Impact factor: 3.465

2.  Lipopolysaccharide sequestrants: structural correlates of activity and toxicity in novel acylhomospermines.

Authors:  Kelly A Miller; E V K Suresh Kumar; Stewart J Wood; Jens R Cromer; Apurba Datta; Sunil A David
Journal:  J Med Chem       Date:  2005-04-07       Impact factor: 7.446

3.  Combination of antimicrobial and endotoxin-neutralizing activities of novel oleoylamines.

Authors:  Mateja Zorko; Andreja Majerle; David Sarlah; Mateja Mancek Keber; Barbara Mohar; Roman Jerala
Journal:  Antimicrob Agents Chemother       Date:  2005-06       Impact factor: 5.191

4.  Anti-endotoxin agents. 2. Pilot high-throughput screening for novel lipopolysaccharide-recognizing motifs in small molecules.

Authors:  Stewart J Wood; Kelly A Miller; Sunil A David
Journal:  Comb Chem High Throughput Screen       Date:  2004-12       Impact factor: 1.339

5.  Structural correlates of antibacterial and membrane-permeabilizing activities in acylpolyamines.

Authors:  Rajalakshmi Balakrishna; Stewart J Wood; Thuan B Nguyen; Kelly A Miller; E V K Suresh Kumar; Apurba Datta; Sunil A David
Journal:  Antimicrob Agents Chemother       Date:  2006-03       Impact factor: 5.191

6.  Design and synthesis of N4,N9-disubstituted spermines for non-viral siRNA delivery--structure-activity relationship studies of siFection efficiency versus toxicity.

Authors:  Moustafa K Soltan; Hassan M Ghonaim; Mohamed El Sadek; M Abou Kull; Lubna Abd El-aziz; Ian S Blagbrough
Journal:  Pharm Res       Date:  2008-10-09       Impact factor: 4.200

7.  Protection from endotoxic shock by EVK-203, a novel alkylpolyamine sequestrant of lipopolysaccharide.

Authors:  Thuan B Nguyen; Ashok Kumar Adisechan; E V K Suresh Kumar; Rajalakshmi Balakrishna; Matthew R Kimbrell; Kelly A Miller; Apurba Datta; Sunil A David
Journal:  Bioorg Med Chem       Date:  2007-06-10       Impact factor: 3.641

8.  Structure-activity relationships of lipopolysaccharide sequestration in N-alkylpolyamines.

Authors:  Anurupa Shrestha; Diptesh Sil; Subbalakshmi S Malladi; Hemamali J Warshakoon; Sunil A David
Journal:  Bioorg Med Chem Lett       Date:  2009-03-18       Impact factor: 2.823
  8 in total

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