| Literature DB >> 10987424 |
C A Veale1, V C Alford, D Aharony, D L Banville, R A Bialecki, F J Brown, J R Damewood, C L Dantzman, P D Edwards, R T Jacobs, R C Mauger, M M Murphy, W Palmer, K K Pine, W L Rumsey, L E Garcia-Davenport, A Shaw, G B Steelman, J M Surian, E P Vacek.
Abstract
The cyclic peptide ANP 4-23 and the linear peptide analogue AP-811 have been shown to be selective ANP-CR antagonists. Via alanine scanning and truncation studies we sought to determine which residues in these molecules were important in their binding to the clearance receptor and the relationship between these two molecules. These studies show that several modifications to these compounds are possible which improve physical properties of these molecules while retaining high affinity for the ANP-CR.Entities:
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Year: 2000 PMID： 10987424 DOI： 10.1016/s0960-894x(00)00387-5
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823