Literature DB >> 10987420

The binding of cocaine to cyclodextrins.

N Nesna1, J Lou, R Breslow.   

Abstract

Cocaine binds into beta-cyclodextrin, but not detectably into alpha- or gamma-cyclodextrin, in water solution. NMR studies indicate the geometry of the complex, which is confirmed by molecular mechanics calculations and binding studies on cocaine analogues and cyclodextrin dimers.

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Year:  2000        PMID： 10987420     DOI： 10.1016/s0960-894x(00)00371-1

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

1.  Cardiac depression induced by cocaine or cocaethylene is alleviated by lipid emulsion more effectively than by sulfobutylether-β-cyclodextrin.

Authors:  Michael R Fettiplace; Adrian Pichurko; Richard Ripper; Bocheng Lin; Katarzyna Kowal; Kinga Lis; David Schwartz; Douglas L Feinstein; Israel Rubinstein; Guy Weinberg
Journal:  Acad Emerg Med       Date:  2015-04-23       Impact factor: 3.451

Review 2.  Cyclodextrins in drug delivery: an updated review.

Authors:  Rajeswari Challa; Alka Ahuja; Javed Ali; R K Khar
Journal:  AAPS PharmSciTech       Date:  2005-10-14       Impact factor: 3.246
  2 in total

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