Literature DB >> 10987414

Potent inhibition of retinoic acid metabolism enzyme(s) by novel azolyl retinoids.

V C Njar1, I P Nnane, A M Brodie.   

Abstract

Novel (+/-)-4-azolyl retinoic acid analogues 4, 5, 7 and 8 have been designed and synthesized and have been shown to be powerful inhibitors of hamster microsomal all-trans-retinoic acid 4-hydroxylase enzyme(s). (+/-)-4-(1H-Imidazol-1-yl)retinoic acid (4) is the most potent inhibitor of this enzyme reported to date.

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Year:  2000        PMID： 10987414     DOI： 10.1016/s0960-894x(00)00391-7

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  8 in total

1.  First chemical feature-based pharmacophore modeling of potent retinoidal retinoic acid metabolism blocking agents (RAMBAs): identification of novel RAMBA scaffolds.

Authors:  Puranik Purushottamachar; Jyoti B Patel; Lalji K Gediya; Omoshile O Clement; Vincent C O Njar
Journal:  Eur J Med Chem       Date:  2011-11-17       Impact factor: 6.514

2.  Anti-tumor effects of a novel retinoic acid metabolism blocking agent VN/14-1 in the N-methyl-N-nitrosourea-induced rat mammary carcinoma model and its effects on the uterus.

Authors:  Paul E Goss; Shangle Qi; Haiqing Hu; Lalji K Gediya; Puranik Purushottamachar; Abhijit M Godbole; Vincent C O Njar
Journal:  Breast Cancer Res Treat       Date:  2011-08-14       Impact factor: 4.872

Review 3.  Therapeutic potential of the inhibition of the retinoic acid hydroxylases CYP26A1 and CYP26B1 by xenobiotics.

Authors:  Cara H Nelson; Brian R Buttrick; Nina Isoherranen
Journal:  Curr Top Med Chem       Date:  2013       Impact factor: 3.295

4.  Inhibition of oxidative metabolism of tocopherols with omega-N-heterocyclic derivatives of vitamin E.

Authors:  Stephan Ohnmacht; Phillip Nava; Ryan West; Robert Parker; Jeffrey Atkinson
Journal:  Bioorg Med Chem       Date:  2008-07-13       Impact factor: 3.641

Review 5.  Targeting cytochrome P450 enzymes: a new approach in anti-cancer drug development.

Authors:  Robert D Bruno; Vincent C O Njar
Journal:  Bioorg Med Chem       Date:  2007-05-23       Impact factor: 3.641

6.  Study on cytochrome p-450 dependent retinoic Acid metabolism and its inhibitors as potential agents for cancer therapy.

Authors:  Mobasher Ahmad
Journal:  Sci Pharm       Date:  2011-08-12

7.  Novel retinoic acid metabolism blocking agents have potent inhibitory activities on human breast cancer cells and tumour growth.

Authors:  J B Patel; J Mehta; A Belosay; G Sabnis; A Khandelwal; A M H Brodie; D R Soprano; V C O Njar
Journal:  Br J Cancer       Date:  2007-03-27       Impact factor: 7.640

8.  Inhibitory effects of retinoic acid metabolism blocking agents (RAMBAs) on the growth of human prostate cancer cells and LNCaP prostate tumour xenografts in SCID mice.

Authors:  C K Huynh; A M H Brodie; V C O Njar
Journal:  Br J Cancer       Date:  2006-02-27       Impact factor: 7.640
  8 in total

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