Literature DB >> 10987412

DNA triple helix stabilization by aminoglycoside antibiotics.

D P Arya1, R L Coffee.   

Abstract

The stabilization of the poly(dA) x 2poly(dT) triple helix by neomycin is reported. Preliminary results indicate that neomycin stabilizes DNA triple helices and the double helical structures composed of poly(dA) x poly(dT) are virtually unaffected. This is the first report of the interaction of aminoglycoside antibiotics with DNA triple helices.

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Year:  2000        PMID： 10987412     DOI： 10.1016/s0960-894x(00)00372-3

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  14 in total

1.  Click dimers to target HIV TAR RNA conformation.

Authors:  Sunil Kumar; Patrick Kellish; W Edward Robinson; Deyun Wang; Daniel H Appella; Dev P Arya
Journal:  Biochemistry       Date:  2012-03-09       Impact factor: 3.162

2.  A peptide nucleic acid-aminosugar conjugate targeting transactivation response element of HIV-1 RNA genome shows a high bioavailability in human cells and strongly inhibits tat-mediated transactivation of HIV-1 transcription.

Authors:  Indrajit Das; Jérôme Désiré; Dinesh Manvar; Isabelle Baussanne; Virendra N Pandey; Jean-Luc Décout
Journal:  J Med Chem       Date:  2012-06-22       Impact factor: 7.446

Review 3.  New approaches toward recognition of nucleic acid triple helices.

Authors:  Dev P Arya
Journal:  Acc Chem Res       Date:  2010-11-12       Impact factor: 22.384

4.  Thermodynamics of nucleic acid "shape readout" by an aminosugar.

Authors:  Hongjuan Xi; Erik Davis; Nihar Ranjan; Liang Xue; David Hyde-Volpe; Dev P Arya
Journal:  Biochemistry       Date:  2011-10-03       Impact factor: 3.162

5.  Aminoglycoside binding to Oxytricha nova telomeric DNA.

Authors:  Nihar Ranjan; Katrine F Andreasen; Sunil Kumar; David Hyde-Volpe; Dev P Arya
Journal:  Biochemistry       Date:  2010-10-22       Impact factor: 3.162

6.  Neomycin-neomycin dimer: an all-carbohydrate scaffold with high affinity for AT-rich DNA duplexes.

Authors:  Sunil Kumar; Liang Xue; Dev P Arya
Journal:  J Am Chem Soc       Date:  2011-04-27       Impact factor: 15.419

7.  Shape readout of AT-rich DNA by carbohydrates.

Authors:  Sunil Kumar; Meredith Newby Spano; Dev P Arya
Journal:  Biopolymers       Date:  2014-07       Impact factor: 2.505

8.  Probing the recognition surface of a DNA triplex: binding studies with intercalator-neomycin conjugates.

Authors:  Liang Xue; Hongjuan Xi; Sunil Kumar; David Gray; Erik Davis; Paris Hamilton; Michael Skriba; Dev P Arya
Journal:  Biochemistry       Date:  2010-07-06       Impact factor: 3.162

9.  Multivalency in the recognition and antagonism of a HIV TAR RNA-TAT assembly using an aminoglycoside benzimidazole scaffold.

Authors:  Sunil Kumar; Nihar Ranjan; Patrick Kellish; Changjun Gong; Derrick Watkins; Dev P Arya
Journal:  Org Biomol Chem       Date:  2016-02-14       Impact factor: 3.876

10.  Multivalent Amino Sugars to Recognize Different TAR RNA Conformations.

Authors:  Patrick C Kellish; Sunil Kumar; Todd S Mack; Meredith Newby Spano; Mirko Hennig; Dev P Arya
Journal:  Medchemcomm       Date:  2014-05-30       Impact factor: 3.597
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