Biochemical and physiological aspects of ubiquinone function.

The brief review presents evidence that, in addition to the well-known functions of ubiquinone (coenzyme Q) as a component of the mitochondrial respiratory chain, this compound in the reduced form (ubiquinol) functions as an antioxidant. Ubiquinone in a partially reduced form is found in all cell membranes. It protects efficiently not only membrane phospholipids from peroxidation but also mitochondrial DNA and membrane proteins from free-radical-induced oxidative damage. This protective role of ubiquinol is independent of the effect of exogenous antioxidants, such as vitamin E, and it can both prevent the formation of free lipid radicals and eliminate them either directly or by regenerating vitamin E.