OBJECTIVE: To determine trends in the epidemiology of vulvar intraepithelial neoplasia (VIN) and squamous cell carcinoma (SCC) of the vulva in a Central European sample during the last decade. STUDY DESIGN: A total of 366 women with VIN 2 and 3 (n = 128) or vulvar SCC (n = 238) presented within two four-year periods separated by one decade (1985-1988 and 1994-1997). We performed a retrospective analysis of the clinicopathologic records of the cohorts. RESULTS: The number of women with high grade VIN (n = 29 vs. 99) tripled during the last decade, while the incidence of vulvar SCC remained stable. In women < or = 50 years old, the incidence of high grade VIN increased by 392% (n = 12 vs. 59) and of invasive vulvar cancer by 157% (n = 7 vs. 18). In the earlier cohort there were 7/126 (5%) women with invasive vulvar SCC under the age of 50 and, in the latter cohort, 18/112 (16%, P < .01). CONCLUSION: Over the past decade a striking increase occurred in the incidence of VIN and an increase in invasive vulvar SCC in young women.
OBJECTIVE: To determine trends in the epidemiology of vulvar intraepithelial neoplasia (VIN) and squamous cell carcinoma (SCC) of the vulva in a Central European sample during the last decade. STUDY DESIGN: A total of 366 women with VIN 2 and 3 (n = 128) or vulvar SCC (n = 238) presented within two four-year periods separated by one decade (1985-1988 and 1994-1997). We performed a retrospective analysis of the clinicopathologic records of the cohorts. RESULTS: The number of women with high grade VIN (n = 29 vs. 99) tripled during the last decade, while the incidence of vulvar SCC remained stable. In women < or = 50 years old, the incidence of high grade VIN increased by 392% (n = 12 vs. 59) and of invasive vulvar cancer by 157% (n = 7 vs. 18). In the earlier cohort there were 7/126 (5%) women with invasive vulvar SCC under the age of 50 and, in the latter cohort, 18/112 (16%, P < .01). CONCLUSION: Over the past decade a striking increase occurred in the incidence of VIN and an increase in invasive vulvar SCC in young women.
Authors: Donata Grimm; Christine Eulenburg; Oliver Brummer; Anna-Katharina Schliedermann; Fabian Trillsch; Katharina Prieske; Friederike Gieseking; Enzia Selka; Sven Mahner; Linn Woelber Journal: Support Care Cancer Date: 2015-06-23 Impact factor: 3.603
Authors: K J Purdie; C A Harwood; K Gibbon; T Chaplin; B D Young; J B Cazier; N Singh; I M Leigh; C M Proby Journal: Br J Cancer Date: 2010-03-16 Impact factor: 7.640
Authors: J J Wallbillich; H E Rhodes; A M Milbourne; M F Munsell; M Frumovitz; J Brown; C L Trimble; K M Schmeler Journal: Gynecol Oncol Date: 2012-08-04 Impact factor: 5.482
Authors: Lucia Six; Sepp Leodolter; Heather L Sings; Eliav Barr; Richard Haupt; Elmar A Joura Journal: Wien Klin Wochenschr Date: 2008 Impact factor: 1.704