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Literature DB >> 10986275

Identification of Brucella abortus OxyR and its role in control of catalase expression.

Abstract

We report the cloning and sequencing of the Brucella abortus oxyR homolog and provide evidence that the transcription product of this gene binds to the B. abortus catalase promoter region. A gene replacement/deletion Brucella oxyR mutant exhibits increased sensitivity to prolonged exposure to H(2)O(2) and is unable to adapt to H(2)O(2) in the environment.

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Year: 2000 PMID： 10986275 PMCID： PMC111015 DOI： 10.1128/JB.182.19.5631-5633.2000

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

22 in total

1. In vivo oxidation-reduction kinetics of OxyR, the transcriptional activator for an oxidative stress-inducible regulon in Escherichia coli.

Authors: K Tao
Journal: FEBS Lett Date: 1999-08-20 Impact factor: 4.124

Review 2. Bacterial evolution.

Authors: C R Woese
Journal: Microbiol Rev Date: 1987-06

Review 3. Mechanisms for redox control of gene expression.

Authors: C E Bauer; S Elsen; T H Bird
Journal: Annu Rev Microbiol Date: 1999 Impact factor: 15.500

4. A large family of bacterial activator proteins.

Authors: S Henikoff; G W Haughn; J M Calvo; J C Wallace
Journal: Proc Natl Acad Sci U S A Date: 1988-09 Impact factor: 11.205

5. Catalases HPI and HPII in Escherichia coli are induced independently.

Authors: P C Loewen; J Switala; B L Triggs-Raine
Journal: Arch Biochem Biophys Date: 1985-11-15 Impact factor: 4.013

Review 6. Molecular biology of the LysR family of transcriptional regulators.

Authors: M A Schell
Journal: Annu Rev Microbiol Date: 1993 Impact factor: 15.500

7. Redox-dependent shift of OxyR-DNA contacts along an extended DNA-binding site: a mechanism for differential promoter selection.

Authors: M B Toledano; I Kullik; F Trinh; P T Baird; T D Schneider; G Storz
Journal: Cell Date: 1994-09-09 Impact factor: 41.582

8. OxyR, a positive regulator of hydrogen peroxide-inducible genes in Escherichia coli and Salmonella typhimurium, is homologous to a family of bacterial regulatory proteins.

Authors: M F Christman; G Storz; B N Ames
Journal: Proc Natl Acad Sci U S A Date: 1989-05 Impact factor: 11.205

9. Construction of Cu-Zn superoxide dismutase deletion mutants of Brucella abortus: analysis of survival in vitro in epithelial and phagocytic cells and in vivo in mice.

Authors: F M Tatum; P G Detilleux; J M Sacks; S M Halling
Journal: Infect Immun Date: 1992-07 Impact factor: 3.441

Identification of Brucella abortus OxyR and its role in control of catalase expression.

1. In vivo oxidation-reduction kinetics of OxyR, the transcriptional activator for an oxidative stress-inducible regulon in Escherichia coli.

Review 2. Bacterial evolution.

Review 3. Mechanisms for redox control of gene expression.

4. A large family of bacterial activator proteins.

5. Catalases HPI and HPII in Escherichia coli are induced independently.

Review 6. Molecular biology of the LysR family of transcriptional regulators.

7. Redox-dependent shift of OxyR-DNA contacts along an extended DNA-binding site: a mechanism for differential promoter selection.

8. OxyR, a positive regulator of hydrogen peroxide-inducible genes in Escherichia coli and Salmonella typhimurium, is homologous to a family of bacterial regulatory proteins.

9. Construction of Cu-Zn superoxide dismutase deletion mutants of Brucella abortus: analysis of survival in vitro in epithelial and phagocytic cells and in vivo in mice.

10. Compartmentalization of catalases in Escherichia coli.

1. Identification of Recombination and Positively Selected Genes in Brucella.

2. Regulation of catalase-peroxidase KatG is OxyR dependent and Fur independent in Caulobacter crescentus.

3. The katA catalase gene is regulated by OxyR in both free-living and symbiotic Sinorhizobium meliloti.

4. OxyR acts as a repressor of catalase expression in Neisseria gonorrhoeae.

5. Acinetobacter baumannii OxyR Regulates the Transcriptional Response to Hydrogen Peroxide.

Review 6. Uncovering the Hidden Credentials of Brucella Virulence.