| Literature DB >> 10986098 |
D R Williams1, M P Clark, U Emde, M A Berliner.
Abstract
A stereoselective synthesis of the C(28)-C(46) fragment (3) of phorboxazole A is described. Key advances include an enantioselective allylation to establish the stereochemistry of the tetrahydropyran unit and a useful SmI(2)-mediated modification of the Barbier reaction of iodomethyloxazole 15 with aldehyde 14.Entities:
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Year: 2000 PMID： 10986098 DOI： 10.1021/ol0063656
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005