| Literature DB >> 10985906 |
Abstract
A number of human cancer cell lines express the PPARgamma transcription factor, and agonists for PPARgamma are reported to promote apoptosis in these cell lines and impede their clonal expansion both in vitro and in vivo. Conjugated linoleic acid (CLA) can activate PPARgamma in rat adipocytes, possibly explaining CLA's antidiabetic effects in Zucker fatty rats. It is thus reasonable to suspect that a portion of CLA's broad spectrum anticarcinogenic activity is mediated by PPARgamma activation in susceptible tumors.Entities:
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Year: 2000 PMID： 10985906 DOI： 10.1054/mehy.1999.1010
Source DB: PubMed Journal: Med Hypotheses ISSN： 0306-9877 Impact factor: 1.538