Literature DB >> 10985083

Diarylheptanoids with in vitro inducible nitric oxide synthesis inhibitory activity from Alnus hirsuta.

M W Lee, N Y Kim, M S Park, K H Ahn, S H Toh, D R Hahn, Y C Kim, H T Chung.   

Abstract

Four diarylheptanoids were isolated from the leaf of Alnus hirsuta (Betulaceae) and have been assessed for nitric oxide (NO) production inhibitory effects in vitro. Oregonin (1) and hirsutanonol (2) were found to be potent inducible nitric oxide synthase (iNOS) inhibitors. Compounds 1 and 2 showed inhibition of NO synthesis in dose-dependent manners by murine macrophage-like RAW 264.7 cells stimulated with interferon-gamma (IFN-gamma) plus lipopolysaccharide (LPS). Their 50% inhibitory concentrations (IC50) were 3.8 and 14.3 microM, respectively. The inhibitory effects of these compounds on NO synthesis were due to suppression of iNOS mRNA expression as determined by Northern blotting.

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Year:  2000        PMID： 10985083     DOI： 10.1055/s-2000-8606

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  8 in total

1.  Diarylheptanoid hirsutenone enhances apoptotic effect of TRAIL on epithelial ovarian carcinoma cell lines via activation of death receptor and mitochondrial pathway.

Authors:  Chung Soo Lee; Eun-Ra Jang; Yun Jeong Kim; Soon Chul Myung; Wonyong Kim; Min Won Lee
Journal:  Invest New Drugs       Date:  2010-12-01       Impact factor: 3.850

2.  Oregonin inhibits lipopolysaccharide-induced iNOS gene transcription and upregulates HO-1 expression in macrophages and microglia.

Authors:  Cheng-Jui Lee; Shoei-Sheng Lee; Su-Chung Chen; Feng-Ming Ho; Wan-Wan Lin
Journal:  Br J Pharmacol       Date:  2005-10       Impact factor: 8.739

3.  Atopic dermatitis-like skin lesions reduced by topical application and intraperitoneal injection of Hirsutenone in NC/Nga mice.

Authors:  Mi Sook Jeong; Sun Eun Choi; Ji Young Kim; Jung Shim Kim; Eun Joo Kim; Kwan Hee Park; Do Ik Lee; Seong Soo Joo; Chung Soo Lee; Hyoweon Bang; Mi-Kyung Lee; Young Wook Choi; Kap-sok Li; Nam Ju Moon; Min Won Lee; Seong Jun Seo
Journal:  Clin Dev Immunol       Date:  2010-12-14

4.  Bioactive constituents and medicinal importance of genus Alnus.

Authors:  Sushil Chandra Sati; Nitin Sati; O P Sati
Journal:  Pharmacogn Rev       Date:  2011-07

Review 5.  The Genus Alnus, A Comprehensive Outline of Its Chemical Constituents and Biological Activities.

Authors:  Xueyang Ren; Ting He; Yanli Chang; Yicheng Zhao; Xiaoyi Chen; Shaojuan Bai; Le Wang; Meng Shen; Gaimei She
Journal:  Molecules       Date:  2017-08-21       Impact factor: 4.411

6.  Anti-Inflammatory and Anti-Oxidative Activities of Phenolic Compounds from Alnus sibirica Stems Fermented by Lactobacillus plantarum subsp. argentoratensis.

Authors:  Thi Tam Le; Jun Yin; MinWon Lee
Journal:  Molecules       Date:  2017-09-18       Impact factor: 4.411

7.  Alnus Sibirica Extracts Suppress the Expression of Inflammatory Cytokines Induced by Lipopolysaccharides, Tumor Necrosis Factor-α, and Interferon-γ in Human Dermal Fibroblasts.

Authors:  Jeongyoon Choi; Sunghee Moon; Hyemi Bae; Young-Won Kim; Donghee Lee; Seongtae Kim; Yelim Seo; Hye Soo Wang; Young Wook Choi; Min Won Lee; Jae-Hong Ko; Inja Lim; Hyoweon Bang
Journal:  Molecules       Date:  2019-08-08       Impact factor: 4.411

8.  Anti-Inflammatory Effects of Alnus Sibirica Extract on In Vitro and In Vivo Models.

Authors:  Jeongyoon Choi; Sunghee Moon; Hyemi Bae; Young-Won Kim; Yelim Seo; Hye Soo Wang; Min Won Lee; Hae Young Yoo; Jung-Ha Kim; Jae-Hong Ko; Inja Lim; Hyoweon Bang
Journal:  Molecules       Date:  2020-03-20       Impact factor: 4.411
  8 in total

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