Literature DB >> 10984618

Expression of T- and L-type calcium channel mRNA in murine sinoatrial node.

G Bohn1, S Moosmang, H Conrad, A Ludwig, F Hofmann, N Klugbauer.   

Abstract

At the cellular level, cardiac pacemaking which sets the rate and rhythm of the heartbeat is produced by the slow diastolic depolarization. Several ion channels contribute to this pacemaker depolarization, including T-type and L-type calcium currents. To evaluate the molecular basis of the currents involved, we investigated the cellular distribution of various low voltage activated (LVA) and high voltage activated (HVA) calcium channel mRNAs in the murine sinoatrial (SA) node by in-situ hybridization. The most prominently expressed LVA calcium channel in the SA node is Ca(v)3.1, whereas Ca(v)3.2 is present at moderate levels. The dominant HVA calcium channel transcript is Ca(v)1.2; only traces of Ca(v)1.3 mRNA are detectable in SA myocytes of mice.

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Year:  2000        PMID： 10984618     DOI： 10.1016/s0014-5793(00)01979-7

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  21 in total

1.  Functional role of L-type Cav1.3 Ca2+ channels in cardiac pacemaker activity.

Authors:  Matteo E Mangoni; Brigitte Couette; Emmanuel Bourinet; Josef Platzer; Daniel Reimer; Jörg Striessnig; Joël Nargeot
Journal:  Proc Natl Acad Sci U S A       Date:  2003-04-16       Impact factor: 11.205

2.  The electrophysiological properties of spontaneously beating pacemaker cells isolated from mouse sinoatrial node.

Authors:  Hyun-Sung Cho; Makoto Takano; Akinori Noma
Journal:  J Physiol       Date:  2003-07-01       Impact factor: 5.182

Review 3.  Low-voltage-activated ("T-Type") calcium channels in review.

Authors:  Anne Marie R Yunker; Maureen W McEnery
Journal:  J Bioenerg Biomembr       Date:  2003-12       Impact factor: 2.945

4.  A molecular signature of tissues with pacemaker activity in the heart and upper urinary tract involves coexpressed hyperpolarization-activated cation and T-type Ca2+ channels.

Authors:  Romulo Hurtado; Gil Bub; Doris Herzlinger
Journal:  FASEB J       Date:  2013-11-04       Impact factor: 5.191

5.  Molecular basis of the T- and L-type Ca2+ currents in canine Purkinje fibres.

Authors:  Barbara Rosati; Wen Dun; Masanori Hirose; Penelope A Boyden; David McKinnon
Journal:  J Physiol       Date:  2007-01-11       Impact factor: 5.182

6.  Dynamical mechanisms of pacemaker generation in IK1-downregulated human ventricular myocytes: insights from bifurcation analyses of a mathematical model.

Authors:  Yasutaka Kurata; Ichiro Hisatome; Hiroyuki Matsuda; Toshishige Shibamoto
Journal:  Biophys J       Date:  2005-07-22       Impact factor: 4.033

7.  Role of ion channels in sepsis-induced atrial tachyarrhythmias in guinea pigs.

Authors:  Yuta Aoki; Noboru Hatakeyama; Seiji Yamamoto; Hiroyuki Kinoshita; Naoyuki Matsuda; Yuichi Hattori; Mitsuaki Yamazaki
Journal:  Br J Pharmacol       Date:  2012-05       Impact factor: 8.739

8.  Genetic enhancement of thalamocortical network activity by elevating alpha 1g-mediated low-voltage-activated calcium current induces pure absence epilepsy.

Authors:  Wayne L Ernst; Yi Zhang; Jong W Yoo; Sara J Ernst; Jeffrey L Noebels
Journal:  J Neurosci       Date:  2009-02-11       Impact factor: 6.167

Review 9.  T-type channels in the sino-atrial and atrioventricular pacemaker mechanism.

Authors:  Pietro Mesirca; Angelo G Torrente; Matteo E Mangoni
Journal:  Pflugers Arch       Date:  2014-02-27       Impact factor: 3.657

10.  Local control of Ca2+-induced Ca2+ release in mouse sinoatrial node cells.

Authors:  Biyi Chen; Yuejin Wu; Peter J Mohler; Mark E Anderson; Long-Sheng Song
Journal:  J Mol Cell Cardiol       Date:  2009-07-15       Impact factor: 5.000
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