Literature DB >> 10983527

Triclabendazole in the treatment of human fascioliasis: a community-based study.

H el-Morshedy1, A Farghaly, S Sharaf, L Abou-Basha, R Barakat.   

Abstract

The efficacy of triclabendazole in the treatment of chronic Fasciola infection was assessed. A total of 134 asymptomatic cases of established Fasciola infection were treated: 68 individuals received a single dose of 10 mg/kg and 66 individuals received 2 doses of 10 mg/kg on 2 consecutive days. Cure was assessed 5 weeks after treatment and 79.4% of the first group and 93.9% of the second group were cured. The drug was well tolerated; no serious side-effects were noted. One patient developed biochemical cholestasis the third day after treatment, but her enzyme profiles returned to normal after 2 months. We conclude triclabendazole is a safe and potent fasciolicidic drug.

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Year:  1999        PMID： 10983527

Source DB:  PubMed          Journal:  East Mediterr Health J        ISSN： 1020-3397            Impact factor:   1.628


  6 in total

Review 1.  Present-day anthelmintics and perspectives on future new targets.

Authors:  Amira Taman; Manar Azab
Journal:  Parasitol Res       Date:  2014-06-04       Impact factor: 2.289

Review 2.  Early Postnatal and Preschool-Age Infection by Fasciola spp.: Report of Five Cases from Vietnam and Worldwide Review.

Authors:  Nguyen Van De; Thanh Hoa Le; Veronica H Agramunt; Santiago Mas-Coma
Journal:  Am J Trop Med Hyg       Date:  2020-10       Impact factor: 3.707

3.  Evaluation of nitazoxanide treatment following triclabendazole failure in an outbreak of human fascioliasis in Upper Egypt.

Authors:  Haidi Karam-Allah Ramadan; Waleed Attia Hassan; Nahed Ahmed Elossily; Alzahraa Abdelraouf Ahmad; Adnan Ahmed Mohamed; Alaa Soliman Abd-Elkader; Eman M Nagiub Abdelsalam; Hani M J Khojah
Journal:  PLoS Negl Trop Dis       Date:  2019-09-25

4.  Triclabendazole in the treatment of human fascioliasis: a review.

Authors:  Preetam Gandhi; Esther K Schmitt; Chien-Wei Chen; Sanjay Samantray; Vinay Kumar Venishetty; David Hughes
Journal:  Trans R Soc Trop Med Hyg       Date:  2019-12-01       Impact factor: 2.184

5.  Administration of triclabendazole is safe and effective in controlling fascioliasis in an endemic community of the Bolivian Altiplano.

Authors:  Fidel Villegas; René Angles; René Barrientos; Gary Barrios; María Adela Valero; Kamal Hamed; Heiner Grueninger; Steven K Ault; Antonio Montresor; Dirk Engels; Santiago Mas-Coma; Albis Francesco Gabrielli
Journal:  PLoS Negl Trop Dis       Date:  2012-08-07

Review 6.  A Scoping Review of the Prevalence of Fascioliasis in Malaysia and Risk Factors for Infection.

Authors:  Mohamad Ahmad Najib; Noor Jamil Noor Izani; Wan Abdul Wahab Wan Nor Amilah; Arizam Muhamad Faez; Zainuddin Shafizol
Journal:  Malays J Med Sci       Date:  2020-02-27
  6 in total

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