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Literature DB >> 10980979

The ileal brake: a fifteen-year progress report.

Abstract

The "ileal brake" is the primary inhibitory feedback mechanism to control transit of a meal through the gastrointestinal tract in order to optimize nutrient digestion and absorption. Neurohormonal factors mediating this response continue to be identified. Recently, additional brakes that fine-tune transit have been described. When gut traffic control is disrupted, pathologic states characterized by malabsorption and impaired drug bioavailability manifest as diarrhea and malnutrition. An understanding of the importance of these nutrient-triggered brakes provides essential clues to future treatments of chronic diarrhea, malnutrition, and drug malabsorption.

Entities: Disease

Mesh：

Year: 1999 PMID： 10980979 DOI： 10.1007/s11894-999-0022-6

Source DB: PubMed Journal: Curr Gastroenterol Rep ISSN： 1522-8037

41 in total

1. Colonic fermentation and proximal gastric tone in humans.

Authors: A Ropert; C Cherbut; C Rozé; A Le Quellec; J J Holst; X Fu-Cheng; S Bruley des Varannes; J P Galmiche
Journal: Gastroenterology Date: 1996-08 Impact factor: 22.682

2. Intestinal transit and absorption of soy protein in dogs depend on load and degree of protein hydrolysis.

Authors: X T Zhao; M A McCamish; R H Miller; L Wang; H C Lin
Journal: J Nutr Date: 1997-12 Impact factor: 4.798

3. Bacterial overgrowth, intestinal transit, and nutrition after total gastrectomy. Comparison of a jejunal pouch with Roux-en-Y reconstruction in a prospective random study.

Authors: M K Iivonen; T O Ahola; M J Matikainen
Journal: Scand J Gastroenterol Date: 1998-01 Impact factor: 2.423

4. Accelerated right colonic emptying after simulated upper gut hemorrhage.

Authors: J Hammer; K Lang; K Kletter
Journal: Am J Gastroenterol Date: 1998-04 Impact factor: 10.864

5. Proceedings: the duodenal brake--hormonal or vagal?

Authors: M Shahidullah; T L Kennedy; T G Parks
Journal: Br J Surg Date: 1973-11 Impact factor: 6.939

6. Effect of ileal infusion of intralipid on gastrointestinal transit, ileal flow rate, and carbohydrate absorption in humans after ingestion of a liquid meal.

Authors: A M Holgate; N W Read
Journal: Gastroenterology Date: 1985-04 Impact factor: 22.682

7. Role of the vagus nerve in mediating proximal nutrient-induced glucagon-like peptide-1 secretion.

Authors: A S Rocca; P L Brubaker
Journal: Endocrinology Date: 1999-04 Impact factor: 4.736

8. Fat-induced ileal brake in humans: a dose-dependent phenomenon correlated to the plasma levels of peptide YY.

Authors: L Pironi; V Stanghellini; M Miglioli; R Corinaldesi; R De Giorgio; E Ruggeri; C Tosetti; G Poggioli; A M Morselli Labate; N Monetti
Journal: Gastroenterology Date: 1993-09 Impact factor: 22.682

9. The effect of oleic acid on the human ileal brake and its implications for small intestinal transit of tablet formulations.

Authors: C L Dobson; S S Davis; S Chauhan; R A Sparrow; I R Wilding
Journal: Pharm Res Date: 1999-01 Impact factor: 4.200

10. PYY and GLP-1 contribute to feedback inhibition from the canine ileum and colon.

Authors: J Wen; S F Phillips; M G Sarr; L J Kost; J J Holst
Journal: Am J Physiol Date: 1995-12

22 in total

1. Conditional Gata4 deletion in mice induces bile acid absorption in the proximal small intestine.

Authors: Eva Beuling; Ilona M Kerkhof; Grace A Nicksa; Michael J Giuffrida; Jamie Haywood; Daniel J aan de Kerk; Christina M Piaseckyj; William T Pu; Terry L Buchmiller; Paul A Dawson; Stephen D Krasinski
Journal: Gut Date: 2010-07 Impact factor: 23.059

The ileal brake: a fifteen-year progress report.

1. Colonic fermentation and proximal gastric tone in humans.

2. Intestinal transit and absorption of soy protein in dogs depend on load and degree of protein hydrolysis.

3. Bacterial overgrowth, intestinal transit, and nutrition after total gastrectomy. Comparison of a jejunal pouch with Roux-en-Y reconstruction in a prospective random study.

4. Accelerated right colonic emptying after simulated upper gut hemorrhage.

5. Proceedings: the duodenal brake--hormonal or vagal?

6. Effect of ileal infusion of intralipid on gastrointestinal transit, ileal flow rate, and carbohydrate absorption in humans after ingestion of a liquid meal.

7. Role of the vagus nerve in mediating proximal nutrient-induced glucagon-like peptide-1 secretion.

8. Fat-induced ileal brake in humans: a dose-dependent phenomenon correlated to the plasma levels of peptide YY.

9. The effect of oleic acid on the human ileal brake and its implications for small intestinal transit of tablet formulations.

10. PYY and GLP-1 contribute to feedback inhibition from the canine ileum and colon.

1. Conditional Gata4 deletion in mice induces bile acid absorption in the proximal small intestine.

Review 2. Lipids in the Stomach - Implications for the Evaluation of Food Effects on Oral Drug Absorption.

3. Gastric emptying and postprandial PYY response after biliopancreatic diversion with duodenal switch.

4. Bariatric and Metabolic Therapies Targeting the Small Intestine.

Review 5. Changes in gastrointestinal hormones and leptin after Roux-en-Y gastric bypass procedure: a review.

Review 6. Does the Ileal Brake Contribute to Delayed Gastric Emptying After Pancreatoduodenectomy?

Review 7. Efficacy of Olibra: a 12-week randomized controlled trial and a review of earlier studies.

Review 8. Surgical cure for type 2 diabetes by foregut or hindgut operations: a myth or reality? A systematic review.

Review 9. Nutrition concerns for the patient with gastroparesis.

Review 10. Teduglutide: a review of its use in the treatment of patients with short bowel syndrome.