Natural history of hypertrophic cardiomyopathy.

Hypertrophic cardiomyopathy is a disease of the cardiac sarcomere and is the most common inherited cardiovascular disorder affecting up to 1 in 500 people in the general population. The disease is typified by variable clinical penetrance and heterogeneous clinical expression, resulting in a wide range of clinical manifestations. Most patients have few if any symptoms and a relatively benign clinical course. A minority are at risk of serious complications including ventricular arrhythmia, sudden death, thromboembolism, congestive cardiac failure, heart block, and infective endocarditis. This article reviews the natural history of the disease, with particular emphasis on lessons learned from recent genetic studies.