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Literature DB >> 10980877

Beta-blockers and spironolactone in heart failure.

Abstract

Neurohormonal antagonism is now recognized as an essential treatment modality for heart failure. As a prime example, the benefits of blocking the renin-angiotensin system with angiotensin converting enzyme inhibitors are clearly established for all four New York Heart Association classes. In this clinical trials review, we discuss two other therapies with neurohormonal targets: beta-blockers and the sympathetic nervous system, and the aldosterone antagonist spironolactone.

Entities: Chemical Disease Gene

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Year: 2000 PMID： 10980877 DOI： 10.1007/s11886-000-0003-8

Source DB: PubMed Journal: Curr Cardiol Rep ISSN： 1523-3782 Impact factor: 2.931

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References

11 in total

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Authors:
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Authors: M Packer; M R Bristow; J N Cohn; W S Colucci; M B Fowler; E M Gilbert; N H Shusterman
Journal: N Engl J Med Date: 1996-05-23 Impact factor: 91.245

Beta-blockers and spironolactone in heart failure.

1. Long-term effects of carvedilol in idiopathic dilated cardiomyopathy with persistent left ventricular dysfunction despite chronic metoprolol. The Heart-Muscle Disease Study Group.

2. Beta-blockade in heart failure: a comparison of carvedilol with metoprolol.

3. Effect of chronic beta-adrenergic receptor blockade in congestive cardiomyopathy.

4. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators.

5. Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF)

6. Beta blockers in heart failure: a comparison of a vasodilating beta blocker with metoprolol.

7. The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II): a randomised trial.

Review 8. Pathological hypertrophy and cardiac interstitium. Fibrosis and renin-angiotensin-aldosterone system.

9. Oxidative stress and congestive heart failure.

10. The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. U.S. Carvedilol Heart Failure Study Group.