Literature DB >> 10980867

Gene therapy for restenosis.

R C Smith1, K Walsh.   

Abstract

This review provides an overview of candidate genes that are currently being evaluated for genetic strategies in vascular gene therapy. We discuss treatment strategies that have proven efficacious in limiting postinterventional restenosis through evaluation with in vivo model systems. The candidate strategies utilize genes that are either cytotoxic, regulate vascular smooth muscle cell differentiation or proliferation. In addition, we review oligonuclotide and ribozyme strategies that function by suppressing the expression of cell cycle regulators.

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Year:  2000        PMID： 10980867     DOI： 10.1007/s11886-000-0020-7

Source DB:  PubMed          Journal:  Curr Cardiol Rep        ISSN： 1523-3782            Impact factor:   2.931


  80 in total

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Authors:  R C Smith; D Branellec; D H Gorski; K Guo; H Perlman; J F Dedieu; C Pastore; A Mahfoudi; P Denèfle; J M Isner; K Walsh
Journal:  Genes Dev       Date:  1997-07-01       Impact factor: 11.361

2.  Fas ligand-induced apoptosis as a mechanism of immune privilege.

Authors:  T S Griffith; T Brunner; S M Fletcher; D R Green; T A Ferguson
Journal:  Science       Date:  1995-11-17       Impact factor: 47.728

3.  Local adenovirus-mediated transfer of human endothelial nitric oxide synthase reduces luminal narrowing after coronary angioplasty in pigs.

Authors:  O Varenne; S Pislaru; H Gillijns; N Van Pelt; R D Gerard; P Zoldhelyi; F Van de Werf; D Collen; S P Janssens
Journal:  Circulation       Date:  1998-09-01       Impact factor: 29.690

4.  Inhibition of neointimal cell bcl-x expression induces apoptosis and regression of vascular disease.

Authors:  M J Pollman; J L Hall; M J Mann; L Zhang; G H Gibbons
Journal:  Nat Med       Date:  1998-02       Impact factor: 53.440

5.  Nuclear factor-kappaB activity and arterial response to balloon injury.

Authors:  B Cercek; M Yamashita; P Dimayuga; J Zhu; M C Fishbein; S Kaul; P K Shah; J Nilsson; J Regnstrom
Journal:  Atherosclerosis       Date:  1997-05       Impact factor: 5.162

6.  Arterial remodeling after coronary angioplasty: a serial intravascular ultrasound study.

Authors:  G S Mintz; J J Popma; A D Pichard; K M Kent; L F Satler; C Wong; M K Hong; J A Kovach; M B Leon
Journal:  Circulation       Date:  1996-07-01       Impact factor: 29.690

7.  Inhibition of rat vascular smooth muscle proliferation in vitro and in vivo by bone morphogenetic protein-2.

Authors:  T Nakaoka; K Gonda; T Ogita; Y Otawara-Hamamoto; F Okabe; Y Kira; K Harii; K Miyazono; Y Takuwa; T Fujita
Journal:  J Clin Invest       Date:  1997-12-01       Impact factor: 14.808

8.  Efficient inhibition of intimal hyperplasia by adenovirus-mediated inducible nitric oxide synthase gene transfer to rats and pigs in vivo.

Authors:  L L Shears; M R Kibbe; A D Murdock; T R Billiar; A Lizonova; I Kovesdi; S C Watkins; E Tzeng
Journal:  J Am Coll Surg       Date:  1998-09       Impact factor: 6.113

9.  Improvement of relaxation in an atherosclerotic artery by gene transfer of endothelial nitric oxide synthase.

Authors:  H Ooboshi; K Toyoda; F M Faraci; M G Lang; D D Heistad
Journal:  Arterioscler Thromb Vasc Biol       Date:  1998-11       Impact factor: 8.311

10.  Evidence for apoptosis in advanced human atheroma. Colocalization with interleukin-1 beta-converting enzyme.

Authors:  Y J Geng; P Libby
Journal:  Am J Pathol       Date:  1995-08       Impact factor: 4.307
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