A F al-Mobireek1, A M Darwazeh, M B Hassanin. 1. Department of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.
Abstract
OBJECTIVE: To correlate the clinical and radiographic changes at different stages of experimentally-induced rheumatoid arthritis (RA) of the TMJ. METHODS: Forty eight adult male guinea pigs, aged 4-6 months, were divided into two groups. Arthritis was induced in the experimental animals by intraperitoneal injection of heat-inactivated group A Streptococcus pyogenes. Four animals from each group were sacrificed and examined clinically and radiographically at intervals of 48 h and 1, 2, 4, 6 and 8 weeks. RESULTS: The main clinical findings were stiffness, crepitation and reduction in mouth opening. Radiographically, the main features were condylar erosion, flattening and sclerosis subcortical cyst formation. CONCLUSION: RA passes through stages that can be correlated clinically and radiographically. Both the clinical and radiographic manifestations in this experimental model are comparable with those previously reported in the small joints of humans.
OBJECTIVE: To correlate the clinical and radiographic changes at different stages of experimentally-induced rheumatoid arthritis (RA) of the TMJ. METHODS: Forty eight adult male guinea pigs, aged 4-6 months, were divided into two groups. Arthritis was induced in the experimental animals by intraperitoneal injection of heat-inactivated group A Streptococcus pyogenes. Four animals from each group were sacrificed and examined clinically and radiographically at intervals of 48 h and 1, 2, 4, 6 and 8 weeks. RESULTS: The main clinical findings were stiffness, crepitation and reduction in mouth opening. Radiographically, the main features were condylar erosion, flattening and sclerosis subcortical cyst formation. CONCLUSION:RA passes through stages that can be correlated clinically and radiographically. Both the clinical and radiographic manifestations in this experimental model are comparable with those previously reported in the small joints of humans.
Authors: Hellíada Vasconcelos Chaves; Ronaldo de Albuquerque Ribeiro; André Mattos Brito de Souza; Antonio Alfredo Rodrigues e Silva; Antoniella Souza Gomes; Mariana Lima Vale; Mirna Marques Bezerra; Gerly Anne de Castro Brito Journal: J Biomed Biotechnol Date: 2011-01-03