Literature DB >> 1098023

The metabolism of N4-hydroxycytidine-a mutagen for Salmonella typhimurium.

E Popowska, C Janion.   

Abstract

Salmonella typhimurium cells were grown in the presence of (14C)-N4-hydroxycytidine (N4OHcyd), a mutagenic nucleoside, and labelling in DNA and RNA digest was traced. The results show that this analogue is incorporated into RNA at a level of 40 mug/100 mg, and into DNA with a yield at least 100 times smaller. Some N-minus4OHcyd was rapidly metabolized and labelling was found in all ribo- and deoxyribo-nucleosides.

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Year:  1975        PMID： 1098023      PMCID： PMC343501          DOI： 10.1093/nar/2.7.1143

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  9 in total

1.  The separation of adenosine, guanosine, cytidine and uridine by one-dimensional filter-paper chromatography.

Authors:  B G LANE
Journal:  Biochim Biophys Acta       Date:  1963-05-28

2.  N4-hydroxycytidine-a new mutagen of a base analogue type.

Authors:  E Popowska; C Janion
Journal:  Biochem Biophys Res Commun       Date:  1974-01-23       Impact factor: 3.575

3.  Separation of nucleosides on polyacrylamide gel columns: further developments.

Authors:  G Piperno; G Bernardi
Journal:  Biochim Biophys Acta       Date:  1971-05-27

4.  Purification and properties of Escherichia coli methyl-deficient phenylalanine tRNA.

Authors:  N Biezunski; D Giveon; U Z Littauer
Journal:  Biochim Biophys Acta       Date:  1970-02-18

Review 5.  Pyrimidine metabolism in microorganisms.

Authors:  G A O'Donovan; J Neuhard
Journal:  Bacteriol Rev       Date:  1970-09

6.  Mutants of Salmonella typhimurium requiring cytidine for growth.

Authors:  J Neuhard; J Ingraham
Journal:  J Bacteriol       Date:  1968-06       Impact factor: 3.490

7.  Vegetative bacteriophage lambda-DNA. II. Physical characterization and replication.

Authors:  E T Young; R L Sinsheimer
Journal:  J Mol Biol       Date:  1967-11-28       Impact factor: 5.469

8.  Mitochondrial DNA. II. Structure and physicochemical properties of isolated DNA.

Authors:  M M Nass
Journal:  J Mol Biol       Date:  1969-06-28       Impact factor: 5.469

9.  A sensitive method for the determination of RNA in DNA and vice versa.

Authors:  D S Duch; M Laskowski
Journal:  Anal Biochem       Date:  1971-11       Impact factor: 3.365
  9 in total
  11 in total

1.  Ribonucleoside analogue that blocks replication of bovine viral diarrhea and hepatitis C viruses in culture.

Authors:  Lieven J Stuyver; Tony Whitaker; Tamara R McBrayer; Brenda I Hernandez-Santiago; Stefania Lostia; Phillip M Tharnish; Mangala Ramesh; Chung K Chu; Robert Jordan; Junxing Shi; Suguna Rachakonda; Kyoichi A Watanabe; Michael J Otto; Raymond F Schinazi
Journal:  Antimicrob Agents Chemother       Date:  2003-01       Impact factor: 5.191

2.  Mutagenic nucleoside analog N4-aminocytidine: metabolism, incorporation into DNA, and mutagenesis in Escherichia coli.

Authors:  K Negishi; K Tamanoi; M Ishii; M Kawakami; Y Yamashita; H Hayatsu
Journal:  J Bacteriol       Date:  1988-11       Impact factor: 3.490

3.  Metabolism of the anti-hepatitis C virus nucleoside beta-D-N4-hydroxycytidine in different liver cells.

Authors:  Brenda I Hernandez-Santiago; Thierry Beltran; Lieven Stuyver; Chung K Chu; Raymond F Schinazi
Journal:  Antimicrob Agents Chemother       Date:  2004-12       Impact factor: 5.191

4.  2-(p-Nitrophenyl)-2'-deoxyadenosine, a new type of mutagenic nucleoside.

Authors:  A Matsuda; Y Ohara; T Kakutani; K Negishi; Y Wataya; H Hayatsu; T Ueda
Journal:  Nucleic Acids Res       Date:  1990-04-11       Impact factor: 16.971

5.  On the ability of Salmonella typhimurium cells to form deoxycytidine nucleotides.

Authors:  C Janion
Journal:  Mol Gen Genet       Date:  1977-06-08

6.  N4-aminocytidine, a nucleoside analog that has an exceptionally high mutagenic activity.

Authors:  K Negishi; C Harada; Y Ohara; K Oohara; N Nitta; H Hayatsu
Journal:  Nucleic Acids Res       Date:  1983-08-11       Impact factor: 16.971

7.  YcbX and yiiM, two novel determinants for resistance of Escherichia coli to N-hydroxylated base analogues.

Authors:  Stanislav G Kozmin; Prune Leroy; Youri I Pavlov; Roel M Schaaper
Journal:  Mol Microbiol       Date:  2008-02-26       Impact factor: 3.501

8.  Effect of proofreading and dam-instructed mismatch repair systems on N4-hydroxycytidine-induced mutagenesis.

Authors:  E Sledziewska-Gójska; C Janion
Journal:  Mol Gen Genet       Date:  1982

9.  Selective Inhibition of Enterovirus A Species Members' Reproduction by Furano[2, 3-d]pyrimidine Nucleosides Revealed by Antiviral Activity Profiling against (+)ssRNA Viruses.

Authors:  Liubov I Kozlovskaya; Anastasia D Golinets; Anastasia A Eletskaya; Alexey A Orlov; Vladimir A Palyulin; Sergey N Kochetkov; Liudmila A Alexandrova; Dmitry I Osolodkin
Journal:  ChemistrySelect       Date:  2018-02-27       Impact factor: 2.109

10.  Small-Molecule Antiviral β-d-N 4-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance.

Authors:  Maria L Agostini; Andrea J Pruijssers; James D Chappell; Jennifer Gribble; Xiaotao Lu; Erica L Andres; Gregory R Bluemling; Mark A Lockwood; Timothy P Sheahan; Amy C Sims; Michael G Natchus; Manohar Saindane; Alexander A Kolykhalov; George R Painter; Ralph S Baric; Mark R Denison
Journal:  J Virol       Date:  2019-11-26       Impact factor: 5.103
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