Literature DB >> 10979896

Pertussis toxin sensitization alters the pathogenesis of subsequent respiratory syncytial virus infection.

J E Fischer1, J E Johnson, T R Johnson, B S Graham.   

Abstract

Evidence suggests that both host and viral factors influence disease severity after infection with respiratory syncytial virus (RSV). To characterize the effects of pertussis toxin (PT) sensitization on subsequent RSV infection, BALB/c mice were treated with PT parenterally before RSV challenge. Priming with purified and detoxified PT before RSV challenge increased postchallenge weight loss and mortality. PT priming changed the kinetics, location, and composition of the cellular infiltrate in the lung but altered neither antibody responses nor virus titers. Passive transfer of PT-sensitized splenocytes produced similar responses. Priming with purified, but not genetically detoxified, PT propagated a modest type 2 cytokine response to RSV antigens. However, anti-interleukin-4 treatment before RSV challenge failed to abrogate the effects of PT priming. These data confirm that the preexisting immune environment can change virus-specific immunity and provide both a model for study of RSV disease and evidence that noninfectious immunomodulators may impact pathogen-specific immunity.

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Year:  2000        PMID： 10979896     DOI： 10.1086/315806

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  7 in total

1.  Non-specific effects of standard measles vaccine at 4.5 and 9 months of age on childhood mortality: randomised controlled trial.

Authors:  Peter Aaby; Cesário L Martins; May-Lill Garly; Carlito Balé; Andreas Andersen; Amabelia Rodrigues; Henrik Ravn; Ida M Lisse; Christine S Benn; Hilton C Whittle
Journal:  BMJ       Date:  2010-11-30

2.  Early diphtheria-tetanus-pertussis vaccination associated with higher female mortality and no difference in male mortality in a cohort of low birthweight children: an observational study within a randomised trial.

Authors:  Peter Aaby; Henrik Ravn; Adam Roth; Amabelia Rodrigues; Ida Maria Lisse; Birgitte Rode Diness; Karen Rokkedal Lausch; Najaaraq Lund; Julie Rasmussen; Sofie Biering-Sørensen; Hilton Whittle; Christine Stabell Benn
Journal:  Arch Dis Child       Date:  2012-02-13       Impact factor: 3.791

3.  Immunological Links to Nonspecific Effects of DTwP and BCG Vaccines on Infant Mortality.

Authors:  Mogens Helweg Claesson
Journal:  J Trop Med       Date:  2011-05-05

4.  Bordetella pertussis infection exacerbates influenza virus infection through pertussis toxin-mediated suppression of innate immunity.

Authors:  Victor I Ayala; John R Teijaro; Donna L Farber; Susan G Dorsey; Nicholas H Carbonetti
Journal:  PLoS One       Date:  2011-04-20       Impact factor: 3.240

5.  Testing the hypothesis that diphtheria-tetanus-pertussis vaccine has negative non-specific and sex-differential effects on child survival in high-mortality countries.

Authors:  Peter Aaby; Christine Benn; Jens Nielsen; Ida Maria Lisse; Amabelia Rodrigues; Henrik Ravn
Journal:  BMJ Open       Date:  2012-05-22       Impact factor: 2.692

6.  A randomized trial of a standard dose of Edmonston-Zagreb measles vaccine given at 4.5 months of age: effect on total hospital admissions.

Authors:  Cesario L Martins; Christine S Benn; Andreas Andersen; Carlito Balé; Frederik Schaltz-Buchholzer; Vu An Do; Amabelia Rodrigues; Peter Aaby; Henrik Ravn; Hilton Whittle; May-Lill Garly
Journal:  J Infect Dis       Date:  2014-01-16       Impact factor: 5.226

7.  National Immunization Campaigns with Oral Polio Vaccine Reduce All-Cause Mortality: A Natural Experiment within Seven Randomized Trials.

Authors:  Andreas Andersen; Ane Baerent Fisker; Amabelia Rodrigues; Cesario Martins; Henrik Ravn; Najaaraq Lund; Sofie Biering-Sørensen; Christine Stabell Benn; Peter Aaby
Journal:  Front Public Health       Date:  2018-02-02
  7 in total

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