Sensitivity of the olfactory sense declines with the aging in senescence-accelerated mouse (SAM-P1).

The decline in olfaction with age is well documented in histological, psychological, and electroencephalographical studies. However, there are few electrophysiological studies on changes in the sensitivity of the peripheral olfactory cells with age. We evaluated the behavior, the amplitude of electro-olfactogram (EOG), and the thickness of the olfactory epithelium in the Senescence-Accelerated Mouse (SAM-P1). This strain of mouse exhibits accelerated senescence and age-related pathologies, and it is commonly used as a model for research on aging. Its median survival time is 55 weeks. To ensure our results would be restricted to the olfactory system, we chose vanillin as a stimulus, because this stimulus has no definitive chorda tympani (VII) response, and we verified that it is tasteless. The data demonstrate that olfactory sensitivity to vanillin decreases dramatically with age in these mice, and that this is due to loss in the number of olfactory receptor cells.