Literature DB >> 10977936

Chronic administration of interferon-a decreases blood pressure and heart rate in rats.

S A Gavrilova1, L V Demidov, N A Medvedeva, I P Ashmarin.   

Abstract

We studied the effects of interferon-alpha on rat cardiovascular system. Intravenous administration of intron-A in a dose of 100,000 IU/kg for 3 days led to a permanent and statistically significant decrease in blood pressure (on days 2 and 3) and reduction in heart rate. These effects were not associated with changes in baroreflex regulation of the cardiovascular system.

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Year:  2000        PMID： 10977936     DOI： 10.1007/BF02439787

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  2 in total

1.  Tailored antihypertensive drug therapy prescribed to older women attenuates circulating levels of interleukin-6 and tumor necrosis factor-α.

Authors:  Juliana O Toledo; Clayton F Moraes; Vinícius C Souza; Audrey C Tonet-Furioso; Luís C C Afonso; Cláudio Córdova; Otávio T Nóbrega
Journal:  Clin Interv Aging       Date:  2015-01-09       Impact factor: 4.458

Review 2.  Revisiting Pleiotropic Effects of Type I Interferons: Rationale for Its Prophylactic and Therapeutic Use Against SARS-CoV-2.

Authors:  Diana Garcia-Del-Barco; Daniela Risco-Acevedo; Jorge Berlanga-Acosta; Frank Daniel Martos-Benítez; Gerardo Guillén-Nieto
Journal:  Front Immunol       Date:  2021-03-26       Impact factor: 7.561
  2 in total

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