Literature DB >> 10977816

A revolution in drug discovery. Combinatorial chemistry still needs logic to drive science forward.

N Beeley, A Berger.   

Abstract

Mesh：

Year:  2000        PMID： 10977816      PMCID： PMC1118482          DOI： 10.1136/bmj.321.7261.581

Source DB:  PubMed          Journal:  BMJ        ISSN： 0959-8138


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  6 in total

1.  Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery.

Authors:  R A Houghten; C Pinilla; S E Blondelle; J R Appel; C T Dooley; J H Cuervo
Journal:  Nature       Date:  1991-11-07       Impact factor: 49.962

2.  General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids.

Authors:  R A Houghten
Journal:  Proc Natl Acad Sci U S A       Date:  1985-08       Impact factor: 11.205

3.  Development of somatostatin receptor subtype selective agonists through combinatorial chemistry.

Authors:  S P Rohrer; S C Berk
Journal:  Curr Opin Drug Discov Devel       Date:  1999-07

Review 4.  Automated synthesis of peptides.

Authors:  R B Merrifield
Journal:  Science       Date:  1965-10-08       Impact factor: 47.728

5.  Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid.

Authors:  H M Geysen; R H Meloen; S J Barteling
Journal:  Proc Natl Acad Sci U S A       Date:  1984-07       Impact factor: 11.205

6.  An MTP inhibitor that normalizes atherogenic lipoprotein levels in WHHL rabbits.

Authors:  J R Wetterau; R E Gregg; T W Harrity; C Arbeeny; M Cap; F Connolly; C H Chu; R J George; D A Gordon; H Jamil; K G Jolibois; L K Kunselman; S J Lan; T J Maccagnan; B Ricci; M Yan; D Young; Y Chen; O M Fryszman; J V Logan; C L Musial; M A Poss; J A Robl; L M Simpkins; W A Slusarchyk; R Sulsky; P Taunk; D R Magnin; J A Tino; R M Lawrence; J K Dickson; S A Biller
Journal:  Science       Date:  1998-10-23       Impact factor: 47.728
  6 in total
  2 in total

1.  New drug discovery techniques are not so revolutionary.

Authors:  D F Horrobin
Journal:  BMJ       Date:  2001-01-27

2.  Which PPI?

Authors:  M J Langman
Journal:  Gut       Date:  2001-08       Impact factor: 23.059
  2 in total

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