Literature DB >> 1097693

Quinoxaline studies. 23. Potential antimalarials. Substituted 5,8-dimethoxyquinoxalines.

G H Fisher, H R Moreno, J E Oatis, H P Schultz.   

Abstract

Two series of 2,3-disubstituted 5,8-dimethoxy-6-[N- (omega-dimethylaminoalkyl) amino] quinoxalines were prepared: the first series with identical 2,3-substituents H, CH3, C6H5, C6H4-4-Cl, and CH2C6H5; and the second with identical styryl groups CH=CHC6H5, CH=CHC6H4-4-Cl, CH=CHC6H3-3,4-C12, CH=CHC6H4-4-F, CH=CHC6H4-4-CF3, and CH=CHC6H4-4-NO2. None of the substances possessed antimalarial activity; several were toxic at highest dosage levels.

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Year:  1975        PMID: 1097693     DOI: 10.1021/jm00241a021

Source DB:  PubMed          Journal:  J Med Chem        ISSN: 0022-2623            Impact factor:   7.446


  1 in total

1.  1,4-Di-n-hept-yloxy-2,5-dinitro-benzene.

Authors:  Octavia A Blackburn; Benjamin J Coe; Robert Futhey; Madeleine Helliwell
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-12-04
  1 in total

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