OBJECTIVE: To investigate the incidence of retinopathy in systemic lupus erythematosus (SLE) and to clarify its significance in relation to other clinical manifestations. METHODS: A cross sectional study on lupus retinopathy was made in 69 patients with SLE. One expert ophthalmologist examined the ocular fundi of the lupus patients without any information of their disease state. Clinical and laboratory findings in the patients with retinopathy and those without were compared. RESULTS: Retinopathy was found in 7/69 (10%) patients. The findings included haemorrhages, vasculitis, cotton wool spots, and hard exudates, all of which were considered to reflect vascular damage. Retinopathy was found to be associated with the presence of anticardiolipin antibody (p<0.05) and with central nervous system lupus (p<0.01). The patients with retinopathy had higher levels of serum creatinine than the patients without retinopathy (p<0.01). The disease activity of lupus, as assessed by the maximum SLE disease activity index (SLEDAI) score of the patients, was also significantly higher in the patients with retinopathy (p<0.03). CONCLUSION: Incidence of retinopathy in SLE was similar to that in previous reports and it may reflect tissue microangiopathy, particularly associated with vasculitis or anticardiolipin antibodies, or both.
OBJECTIVE: To investigate the incidence of retinopathy in systemic lupus erythematosus (SLE) and to clarify its significance in relation to other clinical manifestations. METHODS: A cross sectional study on lupus retinopathy was made in 69 patients with SLE. One expert ophthalmologist examined the ocular fundi of the lupuspatients without any information of their disease state. Clinical and laboratory findings in the patients with retinopathy and those without were compared. RESULTS:Retinopathy was found in 7/69 (10%) patients. The findings included haemorrhages, vasculitis, cotton wool spots, and hard exudates, all of which were considered to reflect vascular damage. Retinopathy was found to be associated with the presence of anticardiolipin antibody (p<0.05) and with central nervous system lupus (p<0.01). The patients with retinopathy had higher levels of serum creatinine than the patients without retinopathy (p<0.01). The disease activity of lupus, as assessed by the maximum SLE disease activity index (SLEDAI) score of the patients, was also significantly higher in the patients with retinopathy (p<0.03). CONCLUSION: Incidence of retinopathy in SLE was similar to that in previous reports and it may reflect tissue microangiopathy, particularly associated with vasculitis or anticardiolipin antibodies, or both.
Authors: D Alarcón-Segovia; M Delezé; C V Oria; J Sánchez-Guerrero; L Gómez-Pacheco; J Cabiedes; L Fernández; S Ponce de León Journal: Medicine (Baltimore) Date: 1989-11 Impact factor: 1.889
Authors: E M Tan; A S Cohen; J F Fries; A T Masi; D J McShane; N F Rothfield; J G Schaller; N Talal; R J Winchester Journal: Arthritis Rheum Date: 1982-11
Authors: E N Harris; A E Gharavi; M L Boey; B M Patel; C G Mackworth-Young; S Loizou; G R Hughes Journal: Lancet Date: 1983-11-26 Impact factor: 79.321
Authors: Paola Pinheiro Kahwage; Mariana Paes Leme Ferriani; João M Furtado; Luciana Martins de Carvalho; Gecilmara Salviato Pileggi; Francisco Hugo Rodrigues Gomes; Maria Teresa Terreri; Claudia Saad Magalhães; Rosa Maria Rodrigues Pereira; Silvana Brasilia Sacchetti; Roberto Marini; Eloisa Bonfá; Clovis Artur Silva; Virgínia Paes Leme Ferriani Journal: Clin Rheumatol Date: 2017-01-09 Impact factor: 2.980
Authors: Iñigo Rúa-Figueroa; Celia Erausquin; Celia Rua-Figueroa; Jesús González-Martín; Antonio Naranjo; Soledad Ojeda; Félix Francisco; Juan C Quevedo; Laura Cáceres; Ruben López; Martin Greco; Irene Altabás-González; Yanira Pérez; Francisco Rubiño; Carlos Rodríguez-Lozano Journal: Rheumatol Int Date: 2019-11-27 Impact factor: 2.631
Authors: Gaurav Seth; K G Chengappa; Durga Prasanna Misra; Ramesh Babu; Pooja Belani; K C Shanoj; Gunjan Kumar; Vir Singh Negi Journal: Rheumatol Int Date: 2018-06-13 Impact factor: 2.631