Literature DB >> 10975524

Megavesicles implicated in the rapid transport of intracisternal aggregates across the Golgi stack.

A Volchuk1, M Amherdt, M Ravazzola, B Brügger, V M Rivera, T Clackson, A Perrelet, T H Söllner, J E Rothman, L Orci.   

Abstract

Engineered protein aggregates ranging up to 400 nm in diameter were selectively deposited within the cis-most cisternae of the Golgi stack following a 15 degrees C block. These aggregates are much larger than the standard volume of Golgi vesicles, yet they are transported across the stack within 10 min after warming the cells to 20 degrees C. Serial sectioning reveals that during the peak of anterograde transport, about 20% of the aggregates were enclosed in topologically free "megavesicles" which appear to pinch off from the rims of the cisternae. These megavesicles can explain the rapid transport of aggregates without cisternal progression on this time scale.

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Substances：

Year:  2000        PMID： 10975524     DOI： 10.1016/s0092-8674(00)00039-8

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  45 in total

1.  Anterograde flow of cargo across the golgi stack potentially mediated via bidirectional "percolating" COPI vesicles.

Authors:  L Orci; M Ravazzola; A Volchuk; T Engel; M Gmachl; M Amherdt; A Perrelet; T H Sollner; J E Rothman
Journal:  Proc Natl Acad Sci U S A       Date:  2000-09-12       Impact factor: 11.205

2.  Structure of the Golgi and distribution of reporter molecules at 20 degrees C reveals the complexity of the exit compartments.

Authors:  Mark S Ladinsky; Christine C Wu; Shane McIntosh; J Richard McIntosh; Kathryn E Howell
Journal:  Mol Biol Cell       Date:  2002-08       Impact factor: 4.138

3.  Countercurrent distribution of two distinct SNARE complexes mediating transport within the Golgi stack.

Authors:  Allen Volchuk; Mariella Ravazzola; Alain Perrelet; William S Eng; Maurizio Di Liberto; Oleg Varlamov; Masayoshi Fukasawa; Thomas Engel; Thomas H Söllner; James E Rothman; Lelio Orci
Journal:  Mol Biol Cell       Date:  2004-01-23       Impact factor: 4.138

4.  How the Golgi works: a cisternal progenitor model.

Authors:  Suzanne R Pfeffer
Journal:  Proc Natl Acad Sci U S A       Date:  2010-11-02       Impact factor: 11.205

5.  The differential palmitoylation states of N-Ras and H-Ras determine their distinct Golgi subcompartment localizations.

Authors:  Stephen J Lynch; Harriet Snitkin; Iwona Gumper; Mark R Philips; David Sabatini; Angel Pellicer
Journal:  J Cell Physiol       Date:  2015-03       Impact factor: 6.384

Review 6.  Golgi tubules: their structure, formation and role in intra-Golgi transport.

Authors:  Emma Martínez-Alonso; Mónica Tomás; José A Martínez-Menárguez
Journal:  Histochem Cell Biol       Date:  2013-06-29       Impact factor: 4.304

Review 7.  Golgi's way: a long path toward the new paradigm of the intra-Golgi transport.

Authors:  Alexander A Mironov; Irina V Sesorova; Galina V Beznoussenko
Journal:  Histochem Cell Biol       Date:  2013-09-26       Impact factor: 4.304

8.  Quantitative analysis of intra-Golgi transport shows intercisternal exchange for all cargo.

Authors:  Serge Dmitrieff; Madan Rao; Pierre Sens
Journal:  Proc Natl Acad Sci U S A       Date:  2013-09-09       Impact factor: 11.205

9.  Induction of cortical endoplasmic reticulum by dimerization of a coatomer-binding peptide anchored to endoplasmic reticulum membranes.

Authors:  Grégory Lavieu; Lelio Orci; Lei Shi; Michael Geiling; Mariella Ravazzola; Felix Wieland; Pierre Cosson; James E Rothman
Journal:  Proc Natl Acad Sci U S A       Date:  2010-03-29       Impact factor: 11.205

10.  Transport through the Golgi apparatus by rapid partitioning within a two-phase membrane system.

Authors:  George H Patterson; Koret Hirschberg; Roman S Polishchuk; Daniel Gerlich; Robert D Phair; Jennifer Lippincott-Schwartz
Journal:  Cell       Date:  2008-06-13       Impact factor: 41.582
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