| Literature DB >> 10975519 |
J Y Hsu1, Z W Sun, X Li, M Reuben, K Tatchell, D K Bishop, J M Grushcow, C J Brame, J A Caldwell, D F Hunt, R Lin, M M Smith, C D Allis.
Abstract
Phosphorylation of histone H3 at serine 10 occurs during mitosis and meiosis in a wide range of eukaryotes and has been shown to be required for proper chromosome transmission in Tetrahymena. Here we report that Ipl1/aurora kinase and its genetically interacting phosphatase, Glc7/PP1, are responsible for the balance of H3 phosphorylation during mitosis in Saccharomyces cerevisiae and Caenorhabditis elegans. In these models, both enzymes are required for H3 phosphorylation and chromosome segregation, although a causal link between the two processes has not been demonstrated. Deregulation of human aurora kinases has been implicated in oncogenesis as a consequence of chromosome missegregation. Our findings reveal an enzyme system that regulates chromosome dynamics and controls histone phosphorylation that is conserved among diverse eukaryotes.Entities:
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Year: 2000 PMID： 10975519 DOI： 10.1016/s0092-8674(00)00034-9
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582