| Literature DB >> 1097514 |
D L Gasser, J Palm, N K Gonatas.
Abstract
Injection of guinea pig spinal cord with complete Freund's adjuvant induces EAE in Lewis (Ag-B1) and DA (Ag-B4) rats, but not in rats of the BN (Ag-B3) strain. When BN is crossed with Lewis, susceptibility is determined by a gene linked to the Ag-B histocompatibility locus, but a much more complex mode of inheritance is involved when BN and DA rats are crossed. Six inbred strains possessing the Ag-B1 histocompatibility allele have been found to be susceptible to EAE. Evidence for recombination between the Ag-B locus and the gene determining susceptibility to EAE has not yet been obtained.Entities:
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Year: 1975 PMID： 1097514
Source DB: PubMed Journal: J Immunol ISSN： 0022-1767 Impact factor: 5.422