BACKGROUND: Controversy continues regarding an association between obstetric complications and risk of schizophrenia in early adult life. AIMS: To compare the rate of labour and delivery complications among persons who developed schizophrenia with controls; to establish whether any complication is associated with later schizophrenia. METHOD: We located the labour ward records of 431 individuals with schizophrenia and of same-gender controls from the same hospital birth series. Mothers were matched by age, socio-economic group and parity. Individual complications were evaluated blindly using two obstetric complication scales. RESULTS: Overall, the rate of labour and delivery complications for those who developed schizophrenia did not differ from that of controls. Males who had presented to psychiatric services before the age of 30 had a greater frequency of and more severe labour/delivery complications than their matched controls. CONCLUSIONS: Other than among young-onset males we found no increase in labour and delivery complications among cases.
BACKGROUND: Controversy continues regarding an association between obstetric complications and risk of schizophrenia in early adult life. AIMS: To compare the rate of labour and delivery complications among persons who developed schizophrenia with controls; to establish whether any complication is associated with later schizophrenia. METHOD: We located the labour ward records of 431 individuals with schizophrenia and of same-gender controls from the same hospital birth series. Mothers were matched by age, socio-economic group and parity. Individual complications were evaluated blindly using two obstetric complication scales. RESULTS: Overall, the rate of labour and delivery complications for those who developed schizophrenia did not differ from that of controls. Males who had presented to psychiatric services before the age of 30 had a greater frequency of and more severe labour/delivery complications than their matched controls. CONCLUSIONS: Other than among young-onset males we found no increase in labour and delivery complications among cases.
Authors: Matti Isohanni; Irene Isohanni; Hannu Koponen; Johanna Koskinen; Pekka Laine; Erika Lauronen; Jouko Miettunen; Pirjo Mäki; Kaisa Riala; Sami Räsänen; Kaisa Saari; Pekka Tienari; Juha Veijola; Graham Murray Journal: Curr Psychiatry Rep Date: 2004-06 Impact factor: 5.285
Authors: Tianyang Zhang; Anna Sidorchuk; Laura Sevilla-Cermeño; Alba Vilaplana-Pérez; Zheng Chang; Henrik Larsson; David Mataix-Cols; Lorena Fernández de la Cruz Journal: JAMA Netw Open Date: 2019-08-02
Authors: Christina G S Palmer; Erin Mallery; Joni A Turunen; Hsin-Ju Hsieh; Leena Peltonen; Jouko Lonnqvist; J Arthur Woodward; Janet S Sinsheimer Journal: Schizophr Res Date: 2008-08-09 Impact factor: 4.939