| Literature DB >> 10974615 |
O Açikgöz1, S Gönenç, B M Kayatekin, C Pekçetin, N Uysal, A Dayi, I Semin, A Güre.
Abstract
The administration of methamphetamine to experimental animals results in damage to dopaminergic neurons. In the present study, we demonstrated that a single dose (15 mg/kg) of methamphetamine results in production of oxidative stress as demonstrated by increased thiobarbituric acid reactive substances levels in the rat striatum and prefrontal cortex. In conclusion, the results of present study provide further evidence in support of the notion that oxidative stress may play an important role in the methamphetamine-induced neurotoxicity.Entities:
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Year: 2000 PMID： 10974615 DOI： 10.1016/s0924-977x(00)00103-6
Source DB: PubMed Journal: Eur Neuropsychopharmacol ISSN： 0924-977X Impact factor: 4.600