J W Hopewell1, K R Trott. 1. Normal Tissue Radiobiology Group, The Research Institute (University of Oxford), The Churchill Hospital, Oxford, UK.
Abstract
PURPOSE: To explore the radiobiological evidence for a dependence of normal tissue complication probability on irradiated normal tissue volume. MATERIALS AND METHODS: Data from experimental studies on the volume effect in different organs, using different criteria of structural or functional organ damage and in different animals, were evaluated to investigate the volume effects for structural radiation damage as opposed to functional radiation damage, and the importance of organ anatomy and dose distribution within the organ on the development of chronic radiation damage in the respective organ. RESULTS: There is little or no volume effect for structural radiation damage, however, some very pronounced volume effects have been reported for functional damage. Volume, as such, is not the relevant criterion, since critical, radiosensitive structures are not homogeneously distributed within organs. CONCLUSION: Volume effects in patients and experimental animals are more related to organ anatomy and organ physiology than to cellular radiobiology.
PURPOSE: To explore the radiobiological evidence for a dependence of normal tissue complication probability on irradiated normal tissue volume. MATERIALS AND METHODS: Data from experimental studies on the volume effect in different organs, using different criteria of structural or functional organ damage and in different animals, were evaluated to investigate the volume effects for structural radiation damage as opposed to functional radiation damage, and the importance of organ anatomy and dose distribution within the organ on the development of chronic radiation damage in the respective organ. RESULTS: There is little or no volume effect for structural radiation damage, however, some very pronounced volume effects have been reported for functional damage. Volume, as such, is not the relevant criterion, since critical, radiosensitive structures are not homogeneously distributed within organs. CONCLUSION: Volume effects in patients and experimental animals are more related to organ anatomy and organ physiology than to cellular radiobiology.
Authors: Søren M Bentzen; Louis S Constine; Joseph O Deasy; Avi Eisbruch; Andrew Jackson; Lawrence B Marks; Randall K Ten Haken; Ellen D Yorke Journal: Int J Radiat Oncol Biol Phys Date: 2010-03-01 Impact factor: 7.038
Authors: Blake R Smith; Nicholas P Nelson; Theodore J Geoghegan; Kaustubh A Patwardhan; Patrick M Hill; Jen Yu; Alonso N Gutiérrez; Bryan G Allen; Daniel E Hyer Journal: Med Phys Date: 2022-02-21 Impact factor: 4.071
Authors: Yu S Severyukhin; M Lalkovičová; D M Utina; K N Lyakhova; I A Kolesnikova; M E Ermolaeva; A G Molokanov; V N Gaevsky; D A Komarov; E A Krasavin Journal: Cell Mol Neurobiol Date: 2022-01-04 Impact factor: 5.046
Authors: Brian F Kiesel; Jianxia Guo; Robert A Parise; Raman Venkataramanan; David A Clump; Christopher J Bakkenist; Jan H Beumer Journal: Cancer Chemother Pharmacol Date: 2022-01-23 Impact factor: 3.288
Authors: Y Prezado; M Dos Santos; W Gonzalez; G Jouvion; C Guardiola; S Heinrich; D Labiod; M Juchaux; L Jourdain; C Sebrie; F Pouzoulet Journal: Sci Rep Date: 2017-12-11 Impact factor: 4.379
Authors: Gillian C Barnett; Catherine M L West; Alison M Dunning; Rebecca M Elliott; Charlotte E Coles; Paul D P Pharoah; Neil G Burnet Journal: Nat Rev Cancer Date: 2009-01-16 Impact factor: 60.716