| Literature DB >> 1097401 |
Abstract
The degree to which the rate of deoxyribonucleic acid synthesis in thy- cultures of Escherichia coli is stimulated after a period of thymine starvation is shown to be a function of the concentration of thymine present as well as of the culture doubling time. Inhibition of deoxyribonucleic acid synthesis by nalidixic acid yields comparable results. Periods of thymine starvation exceeding one doubling time appear to cause an irreversible inactivation of a fraction of the replication forks in the culture.Entities:
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Year: 1975 PMID: 1097401 PMCID: PMC246133 DOI: 10.1128/jb.122.3.841-846.1975
Source DB: PubMed Journal: J Bacteriol ISSN: 0021-9193 Impact factor: 3.490