Literature DB >> 10973471

Human Dengue antibodies against structural and nonstructural proteins.

K Valdés1, M Alvarez, M Pupo, S Vázquez, R Rodríguez, M G Guzmán.   

Abstract

Antibodies against dengue virus type 2 and 4 proteins in acute-phase sera of 10 primary and 10 secondary dengue fever and dengue hemorrhagic fever patients were studied by Western blotting. In the first group the immune response was barely detectable, while in the second group more proteins were detected, with a very strong reaction. Anti-NS1 and -NS3 antibodies were detected mainly in secondary cases. Anti-E, -NS3, and -NS5 antibodies were detected in a high number of cases. The possibility of implementing early diagnostic assays for antigen detection is suggested.

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Year:  2000        PMID： 10973471      PMCID： PMC95972          DOI： 10.1128/CDLI.7.5.856-857.2000

Source DB:  PubMed          Journal:  Clin Diagn Lab Immunol        ISSN： 1071-412X


  6 in total

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  6 in total
  38 in total

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8.  A highly conserved region between amino acids 221 and 266 of dengue virus non-structural protein 1 is a major epitope region in infected patients.

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10.  Antibodies to envelope glycoprotein of dengue virus during the natural course of infection are predominantly cross-reactive and recognize epitopes containing highly conserved residues at the fusion loop of domain II.

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Journal:  J Virol       Date:  2008-04-30       Impact factor: 5.103
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