Literature DB >> 10973464

Highly active antiretroviral therapy (HAART) and circulating markers of immune activation: specific effect of HAART on neopterin.

N Amirayan-Chevillard1, H Tissot-Dupont, Y Obadia, H Gallais, J L Mege, C Capo.   

Abstract

The circulating levels of immune activation markers, including neopterin, tumor necrosis factor receptor type II, and interleukin-2 receptors, are increased in human immunodeficiency virus-infected patients. We show here that highly active antiretroviral therapy significantly decreased neopterin levels. This effect is reversible, since neopterin levels increased after the arrest of treatment. Their determination may be useful in the evaluation of the efficacy of antiretroviral therapy.

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Year:  2000        PMID： 10973464      PMCID： PMC95965          DOI： 10.1128/CDLI.7.5.832-834.2000

Source DB:  PubMed          Journal:  Clin Diagn Lab Immunol        ISSN： 1071-412X


  21 in total

1.  Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease.

Authors:  B Autran; G Carcelain; T S Li; C Blanc; D Mathez; R Tubiana; C Katlama; P Debré; J Leibowitch
Journal:  Science       Date:  1997-07-04       Impact factor: 47.728

2.  Serum neopterin changes in HIV-infected subjects: indicator of significant pathology, CD4 T cell changes, and the development of AIDS.

Authors:  R N Melmed; J M Taylor; R Detels; M Bozorgmehri; J L Fahey
Journal:  J Acquir Immune Defic Syndr (1988)       Date:  1989

3.  Serum increases and lymphoid cell surface losses of IL-2 receptor CD25 in HIV infection: distinctive parameters of HIV-induced change.

Authors:  B Hofmann; P Nishanian; J L Fahey; I Esmail; A L Jackson; R Detels; W Cumberland
Journal:  Clin Immunol Immunopathol       Date:  1991-11

4.  Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators.

Authors:  F J Palella; K M Delaney; A C Moorman; M O Loveless; J Fuhrer; G A Satten; D J Aschman; S D Holmberg
Journal:  N Engl J Med       Date:  1998-03-26       Impact factor: 91.245

5.  Predicting clinical progression or death in subjects with early-stage human immunodeficiency virus (HIV) infection: a comparative analysis of quantification of HIV RNA, soluble tumor necrosis factor type II receptors, neopterin, and beta2-microglobulin. Multicenter AIDS Cohort Study.

Authors:  D S Stein; R H Lyles; N M Graham; C J Tassoni; J B Margolick; J P Phair; C Rinaldo; R Detels; A Saah; J Bilello
Journal:  J Infect Dis       Date:  1997-11       Impact factor: 5.226

6.  Serum neopterin level predicts HIV-related mortality but not progression to AIDS or development of neurological disease in gay men and parenteral drug users.

Authors:  N Sacktor; X Liu; M Popescu; K Marder; Y Stern; R Mayeux
Journal:  Arch Neurol       Date:  1995-07

7.  Treatment of human immunodeficiency virus infection with saquinavir, zidovudine, and zalcitabine. AIDS Clinical Trials Group.

Authors:  A C Collier; R W Coombs; D A Schoenfeld; R L Bassett; J Timpone; A Baruch; M Jones; K Facey; C Whitacre; V J McAuliffe; H M Friedman; T C Merigan; R C Reichman; C Hooper; L Corey
Journal:  N Engl J Med       Date:  1996-04-18       Impact factor: 91.245

Review 8.  Markers predicting progression of human immunodeficiency virus-related disease.

Authors:  C M Tsoukas; N F Bernard
Journal:  Clin Microbiol Rev       Date:  1994-01       Impact factor: 26.132

9.  Serum levels of tumor necrosis factor-alpha (TNF alpha) and soluble TNF receptors in human immunodeficiency virus type 1 infection--correlations to clinical, immunologic, and virologic parameters.

Authors:  P Aukrust; N B Liabakk; F Müller; E Lien; T Espevik; S S Frøland
Journal:  J Infect Dis       Date:  1994-02       Impact factor: 5.226

10.  Immune response-associated production of neopterin. Release from macrophages primarily under control of interferon-gamma.

Authors:  C Huber; J R Batchelor; D Fuchs; A Hausen; A Lang; D Niederwieser; G Reibnegger; P Swetly; J Troppmair; H Wachter
Journal:  J Exp Med       Date:  1984-07-01       Impact factor: 14.307
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  10 in total

1.  Plasma levels of soluble CD27: a simple marker to monitor immune activation during potent antiretroviral therapy in HIV-1-infected subjects.

Authors:  A De Milito; S Aleman; R Marenzi; A Sonnerborg; D Fuchs; M Zazzi; F Chiodi; Fuchs D
Journal:  Clin Exp Immunol       Date:  2002-03       Impact factor: 4.330

2.  Simultaneous determination of xanthopterin and isoxanthopterin in human urine by synchronous fluorescence spectroscopy.

Authors:  Yi-Qun Wan; Li-Juan Tang; Ting Tan
Journal:  J Fluoresc       Date:  2010-04-24       Impact factor: 2.217

3.  A randomized trial of vorinostat with treatment interruption after initiating antiretroviral therapy during acute HIV-1 infection.

Authors:  Eugène D M B Kroon; Jintanat Ananworanich; Amélie Pagliuzza; Ajantha Rhodes; Nittaya Phanuphak; Lydie Trautmann; Julie L Mitchell; Michelle Chintanaphol; Jintana Intasan; Suteeraporn Pinyakorn; Khuntalee Benjapornpong; J Judy Chang; Donn J Colby; Nitiya Chomchey; James L K Fletcher; Keith Eubanks; Hua Yang; John Kapson; Ashanti Dantanarayana; Surekha Tennakoon; Robert J Gorelick; Frank Maldarelli; Merlin L Robb; Jerome H Kim; Serena Spudich; Nicolas Chomont; Praphan Phanuphak; Sharon R Lewin; Mark S de Souza
Journal:  J Virus Erad       Date:  2020-07-18

4.  Are plasma biomarkers of immune activation predictive of HIV progression: a longitudinal comparison and analyses in HIV-1 and HIV-2 infections?

Authors:  Samuel Nyamweya; John Townend; Akram Zaman; Sarah Jane Steele; David Jeffries; Sarah Rowland-Jones; Hilton Whittle; Katie L Flanagan; Assan Jaye
Journal:  PLoS One       Date:  2012-09-10       Impact factor: 3.240

Review 5.  Neopterin in Diagnosis and Monitoring of Infectious Diseases.

Authors:  Michael Eisenhut
Journal:  J Biomark       Date:  2013-12-08

6.  Moderate-Intensity Exercise Improves Body Composition and Improves Physiological Markers of Stress in HIV-Infected Men.

Authors:  Wesley David Dudgeon; Jason Reed Jaggers; Kenneth Doyle Phillips; John Larry Durstine; Stephanie E Burgess; George William Lyerly; John Mark Davis; Gregory Alan Hand
Journal:  ISRN AIDS       Date:  2012-12-11

7.  Utility of Serum Neopterin and Serum IL-2 Receptor Levels to Predict Absolute CD4 T Lymphocyte Count in HIV Infected Cases.

Authors:  Sanjim Chadha; Preena Bhalla; Hitender Gautam; Anita Chakravarti; Sanjeev Saini; S Anuradha; Richa Dewan
Journal:  Interdiscip Perspect Infect Dis       Date:  2013-12-05

8.  Serum Levels of Soluble CD40 Ligand and Neopterin in HIV Coinfected Asymptomatic and Symptomatic Visceral Leishmaniasis Patients.

Authors:  Wim Adriaensen; Saïd Abdellati; Saskia van Henten; Yonas Gedamu; Ermias Diro; Florian Vogt; Bewketu Mengesha; Emebet Adem; Luc Kestens; Johan van Griensven
Journal:  Front Cell Infect Microbiol       Date:  2018-12-11       Impact factor: 5.293

9.  Neopterin and Soluble CD14 Levels as Indicators of Immune Activation in Cases with Indeterminate Pattern and True Positive HIV-1 Infection.

Authors:  Hayriye Kırkoyun Uysal; Pari Sohrabi; Zafer Habip; Suat Saribas; Emre Kocazeybek; Fatih Seyhan; Reyhan Calışkan; Esad Bonabi; Pelin Yuksel; Ilhan Birinci; Omer Uysal; Bekir Kocazeybek
Journal:  PLoS One       Date:  2016-03-31       Impact factor: 3.240

10.  Impact of HIV and Type 2 diabetes on Gut Microbiota Diversity, Tryptophan Catabolism and Endothelial Dysfunction.

Authors:  Hedda Hoel; Malene Hove-Skovsgaard; Johannes R Hov; Julie Christine Gaardbo; Kristian Holm; Martin Kummen; Knut Rudi; Felix Nwosu; Jørgen Valeur; Marco Gelpi; Ingebjørg Seljeflot; Per Magne Ueland; Jan Gerstoft; Henrik Ullum; Pål Aukrust; Susanne Dam Nielsen; Marius Trøseid
Journal:  Sci Rep       Date:  2018-04-30       Impact factor: 4.379
  10 in total

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